Malignant neoplasms of the 18 cities of Barretos Regional Health District (RhD), Sao Paulo, Brazil: the importance of a population-based cancer registry

Abstract

Abstract: Population studies have often been used to infer hypotheses about the etiologyof cancer and to identify risk factors, and data have been collected through Population-Based Cancer Registries. The goal of this study is to evaluate malignant neoplasms in the18 cities belonging to the Barretos RHD, São Paulo. This will be an ecological time trendpopulation-based umbrella study that was designed in six tasks. Task 1: In order toimprove the completeness of the information in the RCBP-Barretos database, theintention is to request the probabilistic and deterministic linkage process with the databaseof deaths of the State of São Paulo belonging to the SEADE Foundation. This processwill also allow for the possibility of identifying deaths that occurred in the State of São Paulo, from patients who used to reside in the 18 target cities of this study but could nothave been identified in other reporting sources. Task 2: An evaluation of the quality ofcancer occurrence information retrieved according to IARC criteria will be performed.Task 3: Gross, age-specific and standardized rates of incidence and mortality per 100,000men and women will be calculated by tumor location. Task 4: The annual percentagechange in incidence and mortality rates by tumor location will be determined. Task 5:Survival analyzes by tumor location will be performed using the Kaplan-Meier method.Task 6: Maps will be created and spatial patterns will be evaluated by calculating theGlobal Moran's Index by location of the tumor.