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Clinical, immunological and microbiological evaluation of experimental Gingivitis and peri-implant Mucositis in patients with history of Agressive Periodontal Disease

Grant number: 19/01522-7
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2019
Effective date (End): February 28, 2022
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Enilson Antonio Sallum
Grantee:Tamires Pereira Dutra
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


Gingivitis and Peri-Implant Mucositis are reversible inflammatory diseases, which do not show loss of supportive tissue and leave no sequelae. However despite the apparent similarities, differences in inflammatory response and microbiome may be present between teeth and implants and among patients with a history of disease compared to healthy patients. Knowledge of different microbiological and immunological factors can help in the search for biomarkers for health and disease status. Therefore the objective of this study is to evaluate, through clinical, microbiological and immunological tests, the changes during the experimental Gingivitis and Mucositis model, between teeth and implants, and between patients with a history of aggressive Periodontitis and healthy individuals. 20 patients will be include, 10 healthy and 10 with a history of aggressive Periodontitis. All patients must present the same type of implant and abutments, with prostheses in function for more than 6 months. They should also have a tooth located in the contralateral hemi-arch in a similar position, allowing a comparison with the implant. They will be submitted to the plaque-induced inflammation by suspension of oral hygiene only in the tested areas (tooth/implant), protected by a personalized stent made of plastic, according to the experimental Gingivitis and Mucositis model of 21 days of duration. Clinical parameters will be collected at baseline, 7, 14, 21 and 42 days. The gingival crevicular fluid and peri-implant and biofilm collections will be performed in the same periods. The subgingival biofilm will be analyzed by sequencing of genes by the 16S rRNA. Inflammatory markers according to the multi-assay method (multiplex dosage Magpix") with xPONENT® software. To compare the parameters evaluated, tests will be used (± = 5%). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DUTRA, TAMIRES PEREIRA; SACRAMENTO, CATHARINA MARQUES; NAGAY, BRUNA EGUMI; MAGNO, MARCELA BARAUNA; MARANON-VASQUEZ, GUIDO ARTEMIO; MAIA, LUCIANNE COPLE; SALLUM, ENILSON ANTONIO; SILVERIO RUIZ, KARINA GONZALES. o smokers have a different gingival crevicular fluid cytokine/chemokine profile than nonsmokers in clinically healthy periodontal sites? A systematic review and meta-analysi. CLINICAL ORAL INVESTIGATIONS, v. 26, n. 2, . (19/01522-7, 19/17238-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
DUTRA, Tamires Pereira. Clinical, immunological and microbiological evaluation of experimental gingivitis/peri-implant mucositis in subjects with a history of grade C periodontitis (aggressive periodontitis). 2022. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.

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