Grant number: | 19/07117-7 |
Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
Effective date (Start): | October 01, 2019 |
Effective date (End): | September 30, 2020 |
Field of knowledge: | Health Sciences - Physical Education |
Principal Investigator: | Edilamar Menezes de Oliveira |
Grantee: | Gabriel Cardial Tobias |
Supervisor: | David Charles Lyden |
Host Institution: | Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Research place: | Weill Cornell Medical College, United States |
Associated to the scholarship: | 18/02351-9 - Role of microRNAs to the attenuation of the colon tumor growth induced by aerobic physical activity in mice, BP.DR |
Abstract Pre-metastatic niche is the result of the combined systemic effects of tumor-secreted factors and tumor-shed extracellular vesicles (e.g. exosomes) that promote temporal sequence of events during the evolution of pre-metastatic niche. Aerobic exercise training reduces the incidence of several types of cancer and attenuates tumor growth in different cancer models. However, the effects of exercise training on the pre-metastatic niche are completely unknown. Here, we plan to investigate the functional and molecular mechanism of exercise training on the pre-metastatic niche formation. For a better characterization of exercise training, we will determine the role of acute and chronic aerobic exercise training on mobilization and uptake of tumor-derived exosome by cells at distant sites. Moreover, we will verify the ability of skeletal muscle-derived exosomes to compete with cancer-derived exosomes for being uptaken by cells at distant sites. Finally, we will investigate the effects of exercise training skeletal muscle-derived exosomes on bone marrow education by tumor-derived exosomes. | |
News published in Agência FAPESP Newsletter about the scholarship: | |
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