Scholarship 18/16689-1 - Engenharia bioquímica, Bioetanol - BV FAPESP
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Cellulases production in biorefineries by solid-state fermentation in packed-bed bioreactors

Grant number: 18/16689-1
Support Opportunities:Scholarships in Brazil - Master
Start date until: April 01, 2019
End date until: February 28, 2021
Field of knowledge:Engineering - Chemical Engineering - Chemical Process Industries
Principal Investigator:Fernanda Perpétua Casciatori
Grantee:Natalia Alvarez Rodrigues
Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated research grant:16/10636-8 - From the cell factory to the Biodiesel-Bioethanol integrated biorefinery: a systems approach applied to complex problems in micro and macroscales, AP.BIOEN.TEM

Abstract

At a time when the technological development of a clean and renewable energy matrix is strategic for Brazil, the concept of biorefinery emerges as that of an industry focused on the production of biofuels, with emphasis on bioethanol, in parallel to the production of high value biomolecules aggregate. With focus on the synthesis of second generation ethanol by biochemical route, the production of cellulolytic enzymes inside the industry (in-house) can guarantee self-sufficiency of the unit. For this purpose, solid state fermentation (SSF) is a viable alternative for obtaining these enzymes and other molecules of interest of the biorefinery, either as internal inputs or final products, using as raw materials sub or co-products of the biorefinery itself. In view of the above, this MSc project is focused on the construction and operation of a packed bed bioreactor for the production of cellulases by SSF. Experimental tests will be carried out in a modular packed bed bioreactor, which will be operated in batch mode and in pseudo-continuous mode, unprecedented in an experimental setting. Instrumentation of the equipment for monitoring the process is also planned. At the end of the project, it is expected to have a viable bio-process of obtaining cellulases using SSF bioreactors in a packed bed of practical and economic operation. The project is part of the Biochemical Engineering research area of the Chemical Engineering Department (DEQ) and will assist the Regular Research Project coordinated by the supervisor (Proc. FAPESP 2018/00996-2). It is also related to the Thematic Project (Proc. FAPESP 2016/10636-8) in progress at DEQ/UFSCar. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RODRIGUES, NATALIA A.; KATAYAMA, ERIC T.; CASCIATORI, FERNANDA P.. Alternative strategies to perform solid-state cultivation in a multilayer packed-bed bioreactor: Continuous and cyclic operations. CHEMICAL ENGINEERING JOURNAL, v. 448, p. 12-pg., . (18/16689-1, 18/26097-4, 18/00996-2, 16/10636-8)
DE OLIVEIRA, SAMUEL PRATAVIEIRA; RODRIGUES, NATALIA ALVAREZ; CASCIATORI-FRASSATTO, PRISCILA APARECIDA; CASCIATORI, FERNANDA PERPETUA. Solid-liquid extraction of cellulases from fungal solid-state cultivation in a packed bed bioreactor. KOREAN JOURNAL OF CHEMICAL ENGINEERING, v. 37, n. 9, . (18/26097-4, 18/16689-1)
DA SILVA, MIRELLA P. DINIZ; DUTRA, RODRIGO SILVA; CASCIATORI, FERNANDA PERPETUA; GRAJALES, LINA MARIA. A two-phase model for simulation of water transfer during lipase production by solid-state cultivation in a tray bioreactor using babassu residues as substrate. CHEMICAL ENGINEERING AND PROCESSING, v. 177, p. 14-pg., . (16/10636-8, 18/26097-4, 18/00996-2, 18/16689-1)

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