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Computational fluid dynamics (CFD) study of a multiphase microorganism propagation step of a high-density bioreactor STR growth

Grant number: 19/06377-5
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): May 01, 2019
Effective date (End): June 30, 2021
Field of knowledge:Engineering - Chemical Engineering
Principal Investigator:José Luís de Paiva
Grantee:André Martins Berger Peralta
Host Institution: Escola Politécnica (EP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:17/50343-2 - Institutional development plan in the area of digital transformation: advanced manufacturing and smart and sustainable cities (PDIp), AP.PDIP


A study of a computational model for the performance simulation of bioreactors - agitated and aerated tanks - for a high-density cell growth is proposed. This research project is related to the area of bio-physics-chemical modeling of IPT's Institutional development plan (PDIP) in the area of Digital Transformation: Advanced Manufacturing and Sustainable Smart Cities (Fapesp Process 17/50343-2). The validation of the model will be made through literature data and experimental results acquired from LBI's - Laboratório de Biotecnologia Industrial (Industrial biotechnology lab) - pilot plant inserted in IPT's Bionanomanufacture center. It is intended to implement a multiphase flow model applied to the stage of propagation of microorganisms in STR bioreactor to obtain high density culture. The models will be implemented via ANSYS-CFX code and should consider the mass and momentum balances of the liquid and gas phases and mass transfer models. Different operating conditions will be investigated: capacity of the bioreactor, type of agitator, speed of rotation and gas flow and impact on the performance of the reactor for the system being studied. This way, there is a reduction in the number of laboratory tests and consequently the resulting costs. The mastery of these tools will provide an analysis of the usual scale-up procedures for bioreactors and the establishment of new criteria and procedures for the design of industrial scale bioreactors. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PERALTA, André Martins Berger. Multiphase Computational Fluid Dynamics (CFD) study of the propagation step of microorganisms in STR bioreactor to obtain high cell density culture.. 2022. Master's Dissertation - Universidade de São Paulo (USP). Escola Politécnica (EP/BC) São Paulo.

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