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Development and analysis of bioactive scaffolds for dentin regeneration

Grant number: 19/06884-4
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): May 01, 2019
Effective date (End): June 30, 2021
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal Investigator:Diana Gabriela Soares dos Passos
Grantee:Camila Correa da Silva Braga de Melo
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
Associated research grant:16/15674-5 - Association of tissue engineering techniques for mineralized tissue regeneration under degenerative inflammatory stimulus: analysis on 3D-culture perfusion bioreactor and animal inflammatory models, AP.JP


Direct pulp capping is a therapy with a limited number of clinical options, which is based on materials that cause coagulation necrosis of pulp tissue, followed by tissue regeneration mediated by the regenerative potential of dental pulp stem cells (DPSCs). The aim of this research project is to develop macro-porous chitosan scaffolds capable to activate reparative dentinogenesis process by DPSCs for dentin repair. The scaffold development will be based on the association of different tissue engineering techniques with the aim of obtaining an interconnected macro-porous network to allow cell infiltration. Following formulation and preparation technique selection, the scaffolds will be submitted to a hydroxyapatite biomineralization process by incubation in simulated body fluid. The DPSCs will be seeded on selected scaffolds, and the following parameters will be evaluated: chemotaxis, cell viability, cell proliferation, cell migration inside scaffold structure, odontogenic differentiation and mineralized matrix deposition. Numerical data will be subjected to statistical analysis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA BRAGA MELO, CAMILA CORREA; CASSIANO, FERNANDA BALESTRERO; BRONZE-UHLE, ERIKA SOARES; STUANI, VITOR DE TOLEDO; FERREIRA BORDINI, ESTER ALVES; GALLINARI, MARJORIE DE OLIVEIRA; SOUZA COSTA, CARLOS ALBERTO; SOARES, DIANA GABRIELA. Mineral-induced bubbling effect and biomineralization as strategies to create highly porous and bioactive scaffolds for dentin tissue engineering. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 110, n. 8, p. 14-pg., . (16/15674-5, 19/06884-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MELO, Camila Correa da Silva Braga de. Mineral-induced bubbling effect and biomineralization as strategies to create highly porous and bioactive scaffolds for dentin tissue engineering. 2021. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB/SDB) Bauru.

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