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Cubosome drug carriers with bioconjugated functionalities and pH-responsive polymer shells

Grant number: 18/21727-0
Support type:Scholarships abroad - Research
Effective date (Start): November 01, 2019
Effective date (End): October 31, 2020
Field of knowledge:Biological Sciences - Biophysics - Biophysics of Processes and Systems
Principal researcher:Omar Mertins
Grantee:Omar Mertins
Host: Angelina Angelova
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Research place: Université Paris-Sud, Châtenay-Malabry (Paris 11), France  
Associated research grant:16/13368-4 - Nanostructured systems: from membrane biomimetic models to carriers of bioactives, AP.TEM


Cubosomes represent a nano structured colloidal system with high capacity for encapsulation of drugs and bioactive agents and promising application as a system of controlled release and release thereof. The internal structure of the cubosomes, which consists of three-dimensional networks of lipid bilayers with crystalline topologies, can be redefined by the incorporation of macromolecules providing specific and advantageous characteristics for an application medium. In this project we will be developing composite cubes of lipids and polysaccharides chitosan and alginate, aiming the production of these nano structures with defined characteristics and whose structure is pH-responsive, aiming its application as a drug delivery system for oral administration. The structural and pH-responsive studies of these nano particles and the encapsulation and release capacity of the antioxidant catechin and the anticancer drug docetaxel will be conducted with innovative procedures and techniques. By means of high resolution microscopy with stimulated emission depletion, time-resolved low-angle X-ray scattering, transmission electron cryo-microscopy and high performance liquid chromatography, the internal structure will be known in detail as well as the changes in real time by the incorporation of macromolecules and pH variation. Therefore, in this project we will use new techniques of latest technology to explore its potential in the development of an innovative drug delivery system. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MERTINS, OMAR; MATHEWS, PATRICK D.; ANGELOVA, ANGELINA. Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications. NANOMATERIALS, v. 10, n. 5 MAY 2020. Web of Science Citations: 0.

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