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Defining the role of cementocytes in dental cementum homeostasis during orthodontic movement

Grant number: 18/26341-2
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2019
Effective date (End): April 30, 2021
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Francisco Humberto Nociti Junior
Grantee:Elis Janaína Lira dos Santos
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Associated scholarship(s):19/09435-6 - Defining the role of cementocytes in dental cementum homeostasis during orthodontic movement, BE.EP.DR


Cementocytes not only share morphological features with osteocytes, but also express several common biomakers. However, in contrast to osteocytes, there is a lack of evidence on the potential biological properties of cementocytes. Thus, we hypothesized that cementocytes play an important role in dental cementum homeostasis during Orthodontic Tooth Movement (OTM). In order to test our hypothesis, a comparative and systematic proteomic analysis of the dental cementum will be performed using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), followed by immunohistochemistry (IHC) to validate LC-MS/MS selected findings in areas whether or not occurred orthodontic tooth movement. In addition, morphological and ultrastructural changes in cementocytes will be assessed by transmission electron microscopy, confocal microscopy in samples labeled with fluorescein isothiocyanate and micro-computed tomography. We anticipate we will be able to define the role of cementocytes in dental cementum homeostasis during OTM and also map potential biomolecules critically involved with dental cementum homeostasis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LIRA DOS SANTOS, ELIS J.; DE ALMEIDA, AMANDA B.; CHAVEZ, MICHAEL B.; SALMON, CRISTIANE R.; MOFATTO, LUCIANA S.; CAMARA-SOUZA, MARIANA BARBOSA; TAN, MICHELLE H.; KOLLI, TAMARA N.; MOHAMED, FATMA F.; CHU, EMILY Y.; et al. Orthodontic tooth movement alters cementocyte ultrastructure and cellular cementum proteome signature. BONE, v. 153, . (18/26341-2, 19/09435-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Elis Janaína Lira dos. Defining the role of cementocytes in dental cementum homeostasis. 2021. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.

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