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Use of accelerometers integrated in microelectromechanical systems (MEMS) in identifying distinct patterns of movement in children with different cerebral palsy subtypes and assessing the effects of botulinum neurotoxin type A intervention

Grant number: 18/16103-7
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): April 01, 2019
Effective date (End): March 31, 2021
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Alberto Cliquet Junior
Grantee:Tania Emi Sakanaka
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Cerebral palsy (CP) is a relatively prevalent condition, with an incidence of 1.7 to 3.1 per 1000 live births in high income countries, with higher incidence in low income countries. CP is the most common cause of physical disability in children. Advances in intervention options have been remarkable in recent decades, including botulinum neurotoxin type A (BoNT-A) and intrathecal baclofen applications, improvements in orthopedic surgery and multiprofessional rehabilitation. However, the success rate is still very much dependent on each child's response to the available intervention. Knowledge about this condition is still very limited, with significant gaps in the understanding of its etiology, evaluation, classification, intervention, or influence on the child´s developmental trajectory and management and impact on the family. It is necessary to increase the availability of objective measures to improve the distinction between different motor deficiencies and the different responses that each motor deficiency has for each intervention. The objective of this project is to explore the use of accelerometers integrated in microelectromechanical systems (MEMS) to aid in the clinical evaluation of PC subtype and to verify possible motor functionality changes resulting from medical treatment, in particular the application of BoNT-A, to clinically validate the use of accelerometers as an objective measure of therapeutic efficiency.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SAKANAKA, TANIA E.; LAKIE, MARTIN; REYNOLDS, RAYMOND F.. Individual differences in intrinsic ankle stiffness and their relationship to body sway and ankle torque. PLoS One, v. 16, n. 1, . (18/16103-7)
SAKANAKA, TANIA E.; LAKIE, MARTIN; REYNOLDS, RAYMOND F.. Idiosyncratic Characteristics of Postural Sway in Normal and Perturbed Standing. FRONTIERS IN HUMAN NEUROSCIENCE, v. 15, . (18/16103-7)

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