Advanced search
Start date

Real-time, rapid detection and sequencing of arboviruses in Brazil: Zika, Dengue, Chikungunya and Yellow Fever

Grant number: 18/17176-8
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): January 01, 2019
Effective date (End): October 31, 2021
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Ester Cerdeira Sabino
Grantee:Ingra Morales Claro
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):19/25047-6 - Establishing a rapid and mobile approach to detect new epidemics, BE.EP.DD


Arbovirus infections in Brazil including Zika, Chikungunya, Dengue and Yellow Fever result inconsiderable morbidity and mortality and are pressing public health concerns. However ourunderstanding of these outbreaks is hampered by limited availability of epidemiological surveillance data. Typically these data are generated by molecular diagnostic assays that are expensive to setup and lack specificity. Consequently we have limited understanding of the interplay and interactions between arboviruses in both human and mosquito populations in Brazil, as demonstrated by Zika Virus in Brazil where detection was delayed by at least a year from the true start of the outbreak. Recently we pioneered a new approach to surveillance of arboviruses using portable, real-time nanopore sequencing - so-called 'genomic epidemiology'. This permits sensitive detection and assignment of viruses into genotypes. However, at present, the costs and complexity of this powerful technique (around $100) currently precludes its use as a routine surveillance tool in research and public health laboratory environments. In this proposal we aim to solve three pressing problems with portable sequencing for arbovirusdetection. This continues a highly productive collaboration between the University of São Paulo, the University of Birmingham and the University of Nottingham that has already resulted in very high impact publications in Nature and Nature Protocols (Faria et al. 2017; Quick et al. 2017). This project will have an immediate impact on the surveillance of arboviruses in Brazil and our understanding of this pressing public health problem. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, GIULIA MAGALHAES; CLARO, INGRA MORALES; GROSCHE, VICTORIA RIQUENA; CANDIDO, DARLAN; JOSE, DIEGO PANDELO; ROCHA, ESMENIA COELHO; COLETTI, THAIS DE MOURA; MANULI, ERIKA REGINA; GABURO JR, NELSON; FARIA, NUNO RODRIGUES; et al. Molecular characterization and sequecing analysis of SARS-CoV-2 genome in Minas Gerais, Brazil. BIOLOGICALS, v. 80, p. 10-pg., . (18/17176-8, 18/14389-0, 19/12000-1)
IANI, FELIPE C. M.; GIOVANETTI, MARTA; FONSECA, VAGNER; SOUZA, WILLIAM M.; ADELINO, TALITA E. R.; XAVIER, JOILSON; JESUS, JAQUELINE G.; PEREIRA, MAIRA A.; SILVA, MARCOS V. F.; COSTA, ALANA V. B.; et al. Epidemiology and evolution of Zika virus in Minas Gerais, Southeast Brazil. INFECTION GENETICS AND EVOLUTION, v. 91, . (18/14389-0, 17/13981-0, 18/17176-8, 19/12000-1, 19/24251-9)
FARIA, NUNO R.; MELLAN, THOMAS A.; WHITTAKER, CHARLES; CLARO, INGRA M.; CANDIDO, DARLAN DA S.; MISHRA, SWAPNIL; CRISPIM, MYUKI A. E.; SALES, FLAVIA C.; HAWRYLUK, IWONA; MCCRONE, JOHN T.; et al. Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil. Science, v. 372, n. 6544, p. 815+, . (20/04558-0, 19/21568-1, 19/21301-5, 18/14389-0, 17/13981-0, 20/04272-9, 18/25468-9, 16/18445-7, 19/21858-0, 18/17176-8, 19/12000-1, 19/07544-2, 18/12579-7, 19/24251-9)
CANDIDO, DARLAN S.; CLARO, INGRA M.; DE JESUS, JAQUELINE G.; SOUZA, WILLIAM M.; MOREIRA, FILIPE R. R.; DELLICOUR, SIMON; MELLAN, THOMAS A.; DU PLESSIS, LOUIS; PEREIRA, RAFAEL H. M.; SALES, FLAVIA C. S.; et al. Evolution and epidemic spread of SARS-CoV-2 in Brazil. Science, v. 369, n. 6508, SI, p. 1255+, . (20/04558-0, 16/00194-8, 19/21301-5, 18/14389-0, 18/14933-2, 17/13981-0, 20/04836-0, 18/25468-9, 16/18445-7, 18/09383-3, 18/17176-8, 19/12000-1, 19/07544-2, 19/24251-9)
THAÍS DE MOURA COLETTI; CAMILA MALTA ROMANO; PAULO ROBERTO URBINATTI; RENILDO SOUZA TEIXEIRA; LEILA WEISS DE ALMEIDA PEDROSA; MARCELLO SCHIAVO NARDI; DELSIO NATAL; ANTÔNIO CHARLYS DA COSTA; JAQUELINE GOES DE JESUS; INGRA MORALES CLARO; et al. Characterization of insect-specific Culex flavivirus (Flaviviridae) nucleotide sequences in mosquitoes from urban parks in São Paulo, Brazil. Revista da Sociedade Brasileira de Medicina Tropical, v. 55, . (16/18204-0, 19/12000-1, 10/51230-8, 19/03859-9, 18/14389-0, 17/00021-9, 18/17176-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CLARO, Ingra Morales. Real-time, rapid detection and sequencing of arboviruses in Brazil. 2021. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

Please report errors in scientific publications list by writing to: