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Physicochemical and biological characteristics of new bioceramic reparative materials and tricalcium silicate doped with fluorine ions cements

Grant number: 18/25364-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2019
Effective date (End): November 30, 2020
Field of knowledge:Health Sciences - Dentistry - Endodontics
Principal Investigator:Mario Tanomaru Filho
Grantee:Lívia Bueno Campi
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


New biomaterials based on tricalcium silicate (C3S) are developed for use as repair materials. Recently, tricalcium silicate doped with fluorine ions (C3S-F) was developed with potential use as biomaterial. Subproject 1: The objective of this study will be to evaluate new materials based on tricalcium silicate associated with 30% of the radiopacifier zirconium oxide (ZrO2), compared to BiodentineTM. Subproject 2: It aims to evaluate the BIO C Repair (Angelus®), C3S-F + ZrO2 and white MTA (Angelus®) cements, comparing them with BiodentineTM. Sub-Project 3: The evaluation of BIO-C Pulpo Bioceramic Pediatric pulp capping (cement for pulpotomy and restoration base - Angelus®) and MTA HP Repair (Angelus®), comparing them with BiodentineTM. Subproject 4: Dentin tubes will be prepared from human premolars and filled with the cements of Subproject 3 for the evaluation of the volumetric change and dentine/material interface in Micro-CT. The data obtained for each evaluation will be submitted to the appropriate statistical tests, with significance level 5%. Physicochemical properties, biocompatibility, antimicrobial capacity and bioactive potential will be evaluated. The tests of setting time, radiopacity and solubility will be based on ISO 6876. Volumetric change and flow will be evaluated in Computerized Microtomography (Micro-CT). Human cells from osteoblasts (Saos-2) will be used for analysis of cell viability by MTT and Neutral Red (NR) assays, bioactivity by alkaline phosphatase activity (ALP) and the presence of mineralized area by Red staining of Alizarin (ARS). The Scratch Wound-Healing test will be performed to determine the effects of repair materials on cell migration. Furthermore, the cell adhesion on the surface of the materials tested in Scanning Electron Microscopy (SEM) will be evaluated. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAMPI, LIVIA BUENO; ESTEVES TORRES, FERNANDA FERRARI; RODRIGUES, ELISANDRA MARCIA; GUERREIRO-TANOMARU, JULIANE MARIA; TANOMARU-FILHO, MARIO. hysicochemical and biological properties of new tricalcium silicate-based repair material doped with fluoride ions and zirconium oxide as radiopacifie. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 110, n. 4, . (18/25364-9, 17/14305-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CAMPI, Lívia Bueno. Physico-chemical and biological characteristics of new bioceramic repair materials and cements based on tricalcium silicate doped with fluoride ions. 2020. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araraquara Araraquara.

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