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Noninvasive intracranial pressure monitoring in patients with chronic migraine

Grant number: 18/22999-3
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2019
Effective date (End): October 13, 2020
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal researcher:Anamaria Siriani de Oliveira
Grantee:Denise Martineli Rossi
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:15/18031-5 - Association study of clinical, functional and neuroimaging in women with migraine, AP.TEM


Recent studies have suggested a possible relationship between the dysregulation of cerebrospinal fluid and intracranial pressure in the central nervous system and its relationship with symptoms such as allodynia, hyperalgesia and generalized pain in chronic pain conditions. The role of increased intracranial pressure has also been investigated in patients with chronic migraine whose pathophysiology comprises a complex neurovascular dysfunction. Abnormalities of cerebrospinal fluid pressure waves were demonstrated in patients with a chronic migraine invasive monitoring through a lumbar needle. However, this question has still not been investigated thoroughly considering the risks of the invasive methods of measuring intracranial pressure. A valid method for noninvasive intracranial pressure (ICP-NI) monitoring was patented by Brazilian researchers. Morphological analyzes of the waveforms during ICP-NI monitoring have proved valid to reveal changes in cerebrospinal fluid and intracranial pressure hydrodynamics in patients with some health conditions such as hydrocephalus and cryptococcal meningitis, but it has not been investigated in patients with chronic pain. Therefore, we intend to investigate possible alterations in the ICP-NI waveform morphology in 30 patients with chronic migraine compared to 30 asymptomatic individuals. The ICP-NI will be monitored by means of an extracranial deformation sensor positioned in the frontotemporal region, continuously and simultaneously with the blood pressure and heart rate measurements in the supine position.

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