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Evaluation of osseointegration of ACQUA implants in rats with systemic involvement

Grant number: 18/01610-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2019
Effective date (End): July 05, 2020
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Rosemary Adriana Chierici Marcantonio
Grantee:Felipe Eduardo Pinotti
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The objective of this study is to evaluate the effect of a hydrophilic surface modified by sandblasting and acid etched and maintained in isotonic solution (ACQUA Surface) on the osseointegration of implants in diabetic and nicotine exposed conditions. One hundred twnty eight rats will be use in this study. The first study will asses the effect of the ACQUA surface in diabetic rats. Sixty-four rats will be randomly allocating in 4 groups with 16 animals each: ACQUA/Healthy; ACQUA/Diabetic; Group Machined/Healthy; Group Machined/Diabetic. The animals will be euthanizing at the periods of 15 and 45 days after the implants placement in the rats tibial methaphysis (8 animals group/period). In the second study, 64 rats will be allocated in 4 groups with 16 animals each according the type of implants surface installed in the rats tibias and the systemic condition of the animals: ACQUA/Healthy; ACQUA/Nicotine; Machined/Healthy; Machined/Nicotine. The animals will be euthanizing at the periods of 15 and 45 days after the implants placement (8 animals group/period). The following analysis will be perform: Biomechanical analyzes: It will be perform to analyze the removal torque of the implants; Histometric analyzes: It will be perform to assess the bone-to-implant contact (BIC) and the bone area between the threads (BBT); Microtomograpgy analyzes: to evaluate the bone area around the implants; Bone formation analysis: Fluorocromes (Alizarin and Calcein); Proteomic analysis to evaluate protein expression of possible signaling pathways and Immunohistochemistry analysis: It will be perform to evaluate the expression of the proteins bone morphogenetic protein 2 (BMP2), alkaline phosphatase (AP) and osteocalcin (OCN).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FELIPE EDUARDO PINOTTI; MAURICIO ANDRÉS TINAJERO ARON; GUILHERME JOSÉ PIMENTEL LOPES DE OLIVEIRA; ELCIO MARCANTONIO JUNIOR; ROSEMARY ADRIANA CHIÉRICI MARCANTONIO. Implants with hydrophilic surfaces equalize the osseointegration of implants in normo- and hyperglycaemic rats. Brazilian Dental Journal, v. 33, n. 6, p. 71-77, . (18/01610-0)
FELIPE EDUARDO PINOTTI; MAURÍCIO ANDRÉS TINAJERO ARONI; GUILHERME JOSÉ PIMENTEL LOPES DE OLIVEIRA; BRUNO LUÍS GRACILIANO SILVA; ELCIO MARCANTONIO JUNIOR; ROSEMARY ADRIANA CHIÉRICI MARCANTONIO. Osseointegration of implants with superhydrophilic surfaces in rats with high serum levels of nicotine. Brazilian Dental Journal, v. 34, n. 2, p. 105-112, . (18/01610-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PINOTTI, Felipe Eduardo. Evaluation of the osseointegration of implants with hydrophilic surfaces in rats with systemic involvement. 2021. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araraquara Araraquara.

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