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The influence of the CYP1A2 polymorphism on the physiological responses and performance following acute supplementation with caffeine

Grant number: 17/15314-1
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2019
Effective date (End): February 28, 2021
Field of knowledge:Health Sciences - Physical Education
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Bryan Saunders
Grantee:Gabriel Henrique Castanho Barreto
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:16/50438-0 - Nutritional suplementation and exercise to optimize exercise performance: focus on individual responses and a step towards personalized sports nutrition, AP.JP


Caffeine is the most consumed psychoactive substance in the world. Its properties are valuable in sports, since it acts as an adenosine receptor antagonist, increasing the noradrenaline and dopamine release of the central nervous system, reducing perceived exertion and pain and reducing fatigue. Despite its beneficial effects, some people appear not to benefit from caffeine supplementation, with purported genetic differences considered a contributing factor. It has been hypothesized that the CYP1A2 -163C>A polymorphism is the main gene responsible for these differences, considering that the C-allele carriers are slow metabolizers and could benefit less from caffeine intake when compared to homozygous AA for this gene (fast metabolizers). However, the time-course profile of caffeine in blood, and its derivates (dimethylxanthines), and the relation with genotype have not been shown in the literature. Also, the performance differences between individuals with different genotypes are contradictory and use small sample sizes. The aim of this study is to determine whether there are changes in the time-course of blood caffeine and dimethylxanthines concentration and performance between the different genotypes for CYP1A2.

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SAUNDERS, BRYAN; SAITO, TIEMI; KLOSTERHOFF, RAFAEL; DE OLIVEIRA, LUANA FARIAS; BARRETO, GABRIEL; PERIM, PEDRO; PINTO, ANA JESSICA; LIMA, FERNANDA; DE SAPINTO, ANA LUCIA; GUALANO, BRUNO. ``I put it in my head that the supplement would help me{''}: Open-placebo improves exercise performance in female cyclists. PLoS One, v. 14, n. 9, . (15/26937-4, 16/50438-0, 18/01594-5, 17/15314-1, 17/04973-4)
PERIM, PEDRO; MARTICORENA, FELIPE MIGUEL; RIBEIRO, FELIPE; BARRETO, GABRIEL; GOBBI, NATHAN; KERKSICK, CHAD; DOLAN, EIMEAR; SAUNDERS, BRYAN. Can the Skeletal Muscle Carnosine Response to Beta-Alanine Supplementation Be Optimized?. FRONTIERS IN NUTRITION, v. 6, . (19/05616-6, 18/19981-5, 16/50438-0, 18/01594-5, 17/15314-1, 17/04973-4)
BARRETO, GABRIEL; GRECCO, BEATRIZ; MEROLA, PIETRO; GONCALVES REIS, CAIO EDUARDO; GUALANO, BRUNO; SAUNDERS, BRYAN. Novel insights on caffeine supplementation, CYP1A2 genotype, physiological responses and exercise performance. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 121, n. 3, . (17/15314-1, 17/13552-2, 20/02391-0, 16/50438-0)
BARRETO, GABRIEL; DE OLIVEIRA, LUANA FARIAS; SAITO, TIEMI; KLOSTERHOFF, RAFAEL; PERIM, PEDRO; DOLAN, EIMEAR; PEREIRA, ROSA MARIA R.; CAMPOS-FERRAZ, PATRICIA; LIMA, FERNANDA R.; SAUNDERS, BRYAN. Reduced Endurance Capacity and Suboptimal Energy Availability in Top-Level Female Cyclists. INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE, v. 16, n. 8, p. 1194-1203, . (19/05616-6, 16/50438-0, 18/01594-5, 17/15314-1, 19/26899-6)
SAITO, TIEMI; BARRETO, GABRIEL; SAUNDERS, BRYAN; GUALANO, BRUNO. Is Open-Label Placebo a New Ergogenic Aid? A Commentary on Existing Studies and Guidelines for Future Research. SPORTS MEDICINE, v. 50, n. 7, . (17/15314-1, 16/50438-0, 17/04973-4)

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