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Efficacy of decaffeinated mate tea (Ilex paraguariensis) in the control of anemia in obese wistar rats

Grant number: 18/18148-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2018
Effective date (End): October 31, 2019
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal researcher:Paulo César Ciarlini
Grantee:Eliana Miranda de Souza
Home Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Obesity is a chronic disease of high global incidence that affects humans and domestic animals. There is evidence that the consumption of maté tea (MT) contributes to minimizing the undesirable effects of chronic inflammation caused by excess fat. The chronic inflammatory processes cause anemia by sequestering iron. On the other hand, there is evidence that the consumption of MT affects the absorption of iron necessary for the synthesis of hemoglobin. The therapeutic use of TM is contraindicated in individuals who are sensitive to caffeine and anemic. In this sense, we propose to investigate the hypothesis that decaffeinated MT maintains its capacity to minimize the anemic effects of chronic inflammation caused by excess fat in rats submitted to excessive consumption of cola-based refrigerant. For this, a randomized armored study will be carried out, 60 adult Wistar rats will be randomly fed for 120 days with and without cola-based refrigerant, with and without decaffeinated MT and non-decaffeinated MT treatment. The control group will be compared to the other groups regarding body composition (weight and Lee Index), plasma biochemical profile (Albumin, cholesterol, triglycerides, total iron, and transferrin) and hematological (complete blood count and reticulocyte count). It is hoped that the results obtained will contribute to a better understanding of the action of MT in the control of obesity and iron deficiency anemia. Confirmation of the likely therapeutic benefits of decaffeinated MT will enable it to be consumed in humans and caffeine-sensitive anemic animals.

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