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Glomerular mesangial cells mitochondrial dynamics alterations in hyperglycemia followed by mesenchymal stem cell therapy

Grant number: 17/18072-9
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2019
Effective date (End): January 31, 2020
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Érika Bevilaqua Rangel
Grantee:Christian Sávio Silva
Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil


Diabetes is an epidemic disease with increasing incidence over the world, causing multiple complications. Diabetic Nephropathy is one of the main disturbs caused by diabetic hyperglycemia, which is characterized by progressive loss of glomerular filtration rate and affects over 40% of diabetic patients. Oxidative stress, which is one of the main players in Diabetic Nephropathy pathogenesis development, affects especially, in a way that disturbs oxidative phosphorylation and culminates in even more ROS production. Increasing body of evidences demonstrates mitochondria impairment as a causal link of the main Diabetes damage pathways and also that interventions to equilibrate mitochondria dynamics can prevent alterations caused by hyperglycemia. Mitochondria have a special - however limited - ability to deal with insults, which is called Quality Control Program (biogenesis, mitophagy, fusion, fission). Cell therapy is a promising treatment tool for diabetic nephropathy, and recently it has been demonstrated that besides the well described paracrine effects, mesenchymal stem cells have the ability to directly transfer their own mitochondria to damaged cells. Our research aims to apply stem cell therapy in a diabetic nephropathy in vitro model and also to assess the influence of direct mitochondria transfer in regeneration efficacy. Finally, one of the questions to be elucidated is: what is the importance to have stem cells present and directly making contact with the injured cells? (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SAVIO-SILVA, CHRISTIAN; SOINSKI-SOUSA, POLIANA EVELYN; BALBY-ROCHA, MARIA THERESA A.; LIRA, ADYNA DE OLIVEIRA; RANGEL, ERIKA BEVILAQUA. Mesenchymal stem cell therapy in acute kidney injury (AKI): review and perspectives. Revista da Associação Médica Brasileira, v. 66, n. 1, p. S45-S54, . (17/23195-2, 17/18072-9, 18/24562-1)
SAVIO-SILVA, CHRISTIAN; SOINSKI-SOUSA, POLIANA E.; SIMPLICIO-FILHO, ANTONIO; BASTOS, ROSANA M. C.; BEYERSTEDT, STEPHANY; RANGEL, ERIKA BEVILAQUA. Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 4, . (17/23195-2, 18/24562-1, 17/18072-9)
SAVIO-SILVA, CHRISTIAN; BEYERSTEDT, STEPHANY; SOINSKI-SOUSA, POLIANA E.; CASARO, EXPEDITO B.; BALBY-ROCHA, MARIA THERESA A.; SIMPLICIO-FILHO, ANTONIO; ALVES-SILVA, JAMILLE; RANGEL, ERIKA B.. Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells. STEM CELLS INTERNATIONAL, v. 2020, . (17/18072-9, 19/12636-3, 18/24562-1)
CHRISTIAN SÁVIO-SILVA; POLIANA EVELYN SOINSKI-SOUSA; MARIA THERESA A BALBY-ROCHA; ÁDYNA DE OLIVEIRA LIRA; ÉRIKA BEVILAQUA RANGEL. Mesenchymal stem cell therapy in acute kidney injury (AKI): review and perspectives. Revista da Associação Médica Brasileira, v. 66, p. s45-s54, . (17/18072-9, 17/23195-2, 18/24562-1)

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