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Isolation and identification of green and brown propolis constituents.

Grant number: 18/25010-2
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2019
Effective date (End): November 21, 2021
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Sergio Ricardo Ambrosio
Grantee:Mário Ferreira Conceição Santos
Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
Associated research grant:17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector, AP.TEM

Abstract

Brazilian propolis produced by Apis mellifera, known as green, brown and red, with approximately 200 tons produced per year, are of great economic importance for Brazil, since they are exported to several countries, especially Japan and China. In spite of its wide popular use justified by its diverse biological effects, there are no medicines based on propolis registered at ANVISA to date. In general, there is a need for many studies to be carried out to ensure the safety, efficacy and quality in the development of new medicines based on these natural resources. There is a great demand for chemical, analytical and pharmacological studies, as well as technological development. Therefore, in this postdoctoral project we are proposing to carry out detailed chemical studies of isolation and structural identification of the major and minor metabolites of two distinct classes of propolis, brown and green, since these chemical studies are mandatory to ensure the success of the main scientific and technological objectives presented in the thematic proposal entitled "Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps in the development of the Brazilian propolis sector."

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE LIMA, REGIANE G.; LISONI, FLAVIA C. R.; PICAO, THAIS B.; DOS SANTOS, FRANSERGIO F.; ORENHA, RENATO P.; BORGES, ALEXANDRE; MOLINA, EDUARDO F.; PARREIRA, RENATO L. T.; E SILVA, MARCIO L. A.; SANTOS, MARIO F. C.; et al. In vitro and in silico cytotoxicity of hinokinin-loaded PLGA microparticle systems against tumoral SiHa cells. NATURAL PRODUCT RESEARCH, . (14/07493-5, 18/25010-2)
LIMA, THAIS C.; MAGALHAES, LIZANDRA G.; PAULA, LUCAS A. DE L.; CUNHA, WILSON R.; JANUARIO, ANA H.; PAULETTI, PATRICIA M.; BASTOS, JAIRO K.; DOS SANTOS, FRANSERGIO F.; FORIM, MOACIR R.; LAURENTIZ, ROSANGELA S.; et al. Evaluation of lignan-loaded poly(epsilon-caprolactone) nanoparticles: synthesis, characterization, in vivo and in silico schistosomicidal activity. NATURAL PRODUCT RESEARCH, . (09/15207-4, 10/17378-8, 18/25010-2, 11/07623-8, 11/05952-4)
DOS SANTOS, ROSIANE; MORAIS-URANO, RAQUEL P.; MARCAL, ROSILENE M.; SILVA, GERALDO H.; SANTOS, MARIO F. C.. Acetylcholinesterase and butyrylcholinesterase inhibition by nectriapyrone and tryptophol isolated from endophytic fungus Phomopsis sp.. NATURAL PRODUCT RESEARCH, . (18/25010-2)
INACIO, GABRIEL DA COSTA; BRITTO ALVES, JOAO VICTOR; CONCEICAO SANTOS, MARIO FERREIRA; VACARI, ALESSANDRA MARIELI; FIGUEIREDO, GUSTAVO PINCERATO; BERNARDES, WAGNER ANTONIO; SOLA VENEZIANI, RODRIGO CASSIO; AMBROSIO, SERGIO RICARDO. Feeding deterrence towards Helicoverpa armigera by Tithonia diversifolia tagitinin C-enriched extract. ARABIAN JOURNAL OF CHEMISTRY, v. 13, n. 5, p. 5292-5298, . (18/25010-2)
SANTOS, MARIO F. C.; FELICIANO, CRISTIANE DOS R.; NETO, ALBERT K.; DE PAULA, DANIELA A. CHAGAS; SOARES, MARISI G.. New bicyclic [3.2.1] octane neolignan derivative from Aniba firmula. NATURAL PRODUCT RESEARCH, . (18/25010-2)
E SILVA, MARCIO L. A.; LUCARINI, RODRIGO; DOS SANTOS, FRANSERGIO F.; MARTINS, CARLOS H. G.; PAULETTI, PATRICIA M.; JANUARIO, ANA H.; CONCEICAO SANTOS, MARIO FERREIRA; CUNHA, WILSON R.. Hypoglycemic effect of rosmarinic acid-rich infusion (RosCE) from Origanum vulgare in alloxan-induced diabetic rats. NATURAL PRODUCT RESEARCH, . (18/25010-2, 18/05080-6)
SANTOS, MARIO FERREIRA CONCEICAO; OLIVEIRA, LARISSA COSTA; RIBEIRO, VICTOR PENA; SOARES, MARISI GOMES; MORAE, GABRIEL DE OLIVEIRA ISAC; SARTORI, ALAN GIOVANINI DE OLIVEIRA; ROSALEN, PEDRO LUIZ; BASTOS, JAIRO KENUPP; DE ALENCAR, SEVERINO MATIAS; VENEZIANI, RODRIGO CASSIO SOLA; et al. Isolation of diterpenes from Araucaria sp Brazilian brown propolis and development of a validated high-performance liquid chromatography method for its analysis. JOURNAL OF SEPARATION SCIENCE, v. 44, n. 16, . (17/04138-8, 18/05080-6, 18/25010-2)
PAULA, LUCAS A. DE L.; SANTOS, MARIO F. C.; PAGOTTI, MARIANA C.; VENEZIANI, RODRIGO C. S.; BASTOS, JAIRO K.; CAFFREY, CONOR R.; AMBROSIO, SERGIO R.; MAGALHAES, LIZANDRA G.. razilian green propolis reduces worm burden and hepatic granuloma formation in a Schistosoma mansoni experimental murine mode. Parasitology Research, v. 121, n. 2, p. 775-780, . (18/50011-2, 17/04138-8, 18/25010-2, 18/05080-6)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.