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Evaluation of the efficacy of the combination of treatments with casein phosphorous-amorphous calcium phosphate and sodium trimetaphosphate in reducing tooth enamel demineralization: an in vitro study

Grant number: 18/13258-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2019
Effective date (End): November 30, 2019
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal Investigator:Marcelle Danelon
Grantee:Matheus dos Passos Silva
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The purpose of the present study was to evaluate in vitro the effect of the association of treatments with fluoridated dentifrices and supplemented with sodium trimetaphosphate (TMP) and amorphous calcium casephosphate (CPP-ACP) phosphopeptide (MI Paste Plus®) on the reduction demineralization of dental enamel. Bovine enamel blocks (4 mm × 4 mm, n = 72) will be selected by the initial surface hardness (SHi) and then divided into 6 treatment groups (n = 12): 1) Dentifrice without F (Placebo); 2) Dentifrice with 1100 ppm F (1100F), 3) Dentifrice with 1100 ppm F associated with MI Paste Plus® (1100F/MI Paste Plus®), 4) Dentifrice with 1100 ppm F + 3% TMP (1100F/TMP) 5) MI Paste Plus® and 6) Dentifrice with 1100 ppm F + 3% TMP associated with MI Paste Plus® (1100F/TMP/MI Paste Plus®). The blocks will be treated 2x/day with the dentifrices, being submitted to 5 pH cycling for 7 days. After pH cycling, the final surface hardness (SHf) will be determined for the calculation of percentage of surface hardness loss (%SH) and integrated loss of subsurface hardness (”KHN). The data will be submitted to the normality and homogeneity tests to use the statistical test most appropriate to the data distribution. Sigmaplot © software for Windows version 12.0 will be used with statistical significance at the 5% level.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GONCALVES, FRANCYENNE MAIRA CASTRO; DELBEM, ALBERTO CARLOS BOTAZZO; GOMES, LEONARDO FERNANDES; EMERENCIANO, NAYARA GONCALVES; DOS PASSOS SILVA, MATHEUS; CANNON, MARK L.; DANELON, MARCELLE. Combined effect of casein phosphopeptide-amorphous calcium phosphate and sodium trimetaphosphate on the prevention of enamel demineralization and dental caries: an in vitro study. CLINICAL ORAL INVESTIGATIONS, v. 25, n. 5, p. 10-pg., . (18/13258-0, 18/24761-4)

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