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Development of microfluidic devices/organ on a chip using xurography, poliester-toner and gelatin methacryloyl (GelMA)

Grant number: 18/07342-8
Support Opportunities:Scholarships abroad - Research
Effective date (Start): August 23, 2021
Effective date (End): August 22, 2022
Field of knowledge:Engineering - Biomedical Engineering - Bioengineering
Principal Investigator:Rondinelli Donizetti Herculano
Grantee:Rondinelli Donizetti Herculano
Host Investigator: Alireza Khademhosseini
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Research place: University of California, Los Angeles (UCLA), United States  
Associated research grant:16/01743-5 - The new gestational triad: hyperglycemia, urinary incontinence (UI) and biomolecular profile as a long-term predictor for UI: a prospective cohort study: translational research with biodevice with stem cells for muscle regeneration in diabetic rats, AP.TEM


Evaluation of cytotoxicity of new drugs, compounds and biomaterials using two-dimensional cell culture is an interesting alternative to reduce the use of animals. However, growing cells in flat layers on plastic surfaces does not accurately model the in vivo state. So, organs-on-chips present an ideal microenvironment to mimic a tissue/organ human-specific. The objective of this work is to develop a low cost microfluidic devices based to polyester-toner technique and xurography using cells embedded in gelatin methacrylamide (GelMA) hydrogels. The excellent biocompatibility of GelMA hydrogels makes them suitable as cell culture matrices that mimic native extracellular matrix (ECM). In addition, we will evaluate the vegetable extracts (Stryphnodendron sp and Casearia sylvestris) and latex membrane incorporated with these extracts and their fractions using these microfluidic chips. (AU)

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