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Effects of inbreeding depression on milk production traits in Murrah buffaloes

Grant number: 18/25725-1
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): March 11, 2019
Effective date (End): March 08, 2020
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal Investigator:Humberto Tonhati
Grantee:André Vieira do Nascimento
Supervisor: Cedric Gondro Msu
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Research place: Michigan State University (MSU), United States  
Associated to the scholarship:17/10542-6 - Scaning of selection signatures in dairy buffalo (Bubalus bubalis), BP.DR


Inbreeding results in progeny with reduced heterozygosity, increasing the risk of inbreeding depression (ID), which reduces the average phenotypic value of traits of economic interest. Estimating the coefficient of inbreeding (F) and ID can support breeding programs, enabling the control and maintenance of genetic diversity and avoiding the effects of ID. The aim of this study is to estimate the F by different methods and to evaluate the effects of inbreeding on milk production traits in Murrah buffaloes. A total of 289 dairy buffaloes were genotyped for 90k with Axiom Buffalo Genotyping panel, and another 384 animals will be genotyped with the same panel. The effects of ID on 305-day milk yield, milk fat percent, and milk protein percent will be evaluated. The F will be estimated using genealogical (pedigree, FPED) records and genomic information (runs of homozygosity, FROH; genomic relationship matrix, GRM). The ID will be estimated by the regression of phenotypes on the F. The model for each trait will include the (1) fixed effect of group of contemporaries, (2) buffalo age at calving and each F (FPED, FROH, FGRM_Base, FGRM_Fixed) as covariables, and (3) random effects of genetic additive, permanent environment, and residual effects.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NASCIMENTO, A. V.; ROMERO, A. R. S.; NAWAZ, M. Y.; CARDOSO, D. F.; SANTOS, D. J. A.; GONDRO, C.; TONHATI, H.. An updated Axiom buffalo genotyping array map and mapping of cattle quantitative trait loci to the new water buffalo reference genome assembly. ANIMAL GENETICS, v. 52, n. 4, p. 505-508, . (18/25725-1, 17/10542-6, 16/21213-0)

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