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Search for determinants of antibiotic resistance in the interior of São Paulo using functional metagenomics

Grant number: 18/18158-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): January 01, 2019
Effective date (End): December 31, 2020
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal Investigator:María Eugenia Guazzaroni
Grantee:Gabriel Lencioni Lovate
Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:15/04309-1 - Novel approaches to improve functional screening of biocatalysts in metagenomic libraries, AP.JP


Antibiotics usage from the beginning of the 20th century brought us measurable advances in public health. However, this progress has been threatened by the ubiquitous presence of resistance to our modern antimicrobial therapy. International guidelines incentive and advise about research in the field of antibiotics resistance. This comprehension is invaluable to the design of effective public politics mitigating resistance presence. The set of antibiotic resistance genes (ARGs) in each population is called the resistome. Studies have demonstrated that the resistome can work as an important ARGs reservoir. Nevertheless, the dynamics of resistome development have yet to be uncovered by large scale studies of those genetic determinants. Metagenomic studies of microbial communities has acted as an important tool for the resistome uncovering. Thus, metagenomic approaches can determine ARGs` presence in large scale, not being limited to lab cultured microorganisms. Functional metagenomics is a activity-based screening technique used to search for genes of interest and has the main advantage of not being dependent on previously sequenced genes, allowing to identify novel genes with unique characteristics. This project has the objective of exploring the resistome existing in the city of Ribeirao Preto through functional metagenomics, providing relevant information about ARGs circulating in the interior of the state of São Paulo. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RIBEIRO, LUCAS FERREIRA; AMARELLE, VANESA; ALVES, LUANA DE FATIMA; VIANA DE SIQUEIRA, GUILHERME MARCELINO; LOVATE, GABRIEL LENCIONI; BORELLI, TIAGO CABRAL; GUAZZARONI, MARIA-EUGENIA. Genetically Engineered Proteins to Improve Biomass Conversion: New Advances and Challenges for Tailoring Biocatalysts. Molecules, v. 24, n. 16, . (16/18827-7, 15/04309-1, 18/18158-3, 18/07261-8, 19/00390-0, 16/06323-4)
BORELLI, TIAGO CABRAL; LOVATE, GABRIEL LENCIONI; SCARANELLO, ANA FLAVIA TONELLI; RIBEIRO, LUCAS FERREIRA; ZARAMELA, LIVIA; PEREIRA-DOS-SANTOS, FELIPE MARCELO; SILVA-ROCHA, RAFAEL; GUAZZARONI, MARIA-EUGENIA. Combining Functional Genomics and Whole-Genome Sequencing to Detect Antibiotic Resistance Genes in Bacterial Strains Co-Occurring Simultaneously in a Brazilian Hospital. ANTIBIOTICS-BASEL, v. 10, n. 4, . (19/00390-0, 15/04309-1, 19/06672-7, 16/18827-7, 19/15675-0, 18/18158-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LOVATE, Gabriel Lencioni. Functional genomics approach to identify antibiotic resistance genes. 2020. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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