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Gene interference on the dorsol motor of vagus neurons and its influence on the autonomic dysfunctions of spontaneously hypertensive rats

Grant number: 18/19907-0
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): January 01, 2019
Effective date (End): April 30, 2023
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Vagner Roberto Antunes
Grantee:Karoline Martins dos Santos
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):21/10017-4 - Properties of liver-related PVN-DMV neurons and their role in facilitating the effects of central insulin, BE.EP.DD


I present in this document a proposal of scientific project with the objective of changing scholarship of masters level for a direct doctorate, before my approval on course transference (master to doctorate) happened during the qualification exam. The first objectives proposed on masters project have been achieved until the date, and with the approval to changing of level, we are proposing to expand the project to the doctorate level with experimental approach and methodologies more innovative to answer some questions that appeared during the project's development. Our proposal is to extend the studies on the evaluation of electrophysiological properties of dorsal motor of the vagus neurons that have projections exclusively to the hepatic region on spontaneously hypertensive rats, and its normotensive controls, against pharmacogenetic (DREADD) and non-pharmacological (physical exercise) therapies, detailed all over the document. Furthermore, it is important to highlight that the results obtained so far were presented at the last annual meeting of Federation of Societies of Experimental Biology (FesBE) and my project received the first place in Álvaro Osório de Almeida Award granted by the Brazilian Society of Physiology (SBFis) to young scientists with outstanding and excellence works. Therefore, we hope to count with the appreciation in the judgment of this proposal to change the scholarship level. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SA, RENATO W. MARTINS; THEPARAMBIL, SHEFEEQ M.; DOS SANTOS, KAROLINE MARTINS; CHRISTIE, ISABEL N.; MARINA, NEPHTALI; CARDOSO, BARBARA V.; HOSFORD, PATRICK S.; ANTUNES, VAGNER R.. Salt-loading promotes extracellular ATP release mediated by glial cells in the hypothalamic paraventricular nucleus of rats. Molecular and Cellular Neuroscience, v. 124, p. 9-pg., . (19/19894-8, 16/21991-3, 16/03359-8, 18/19907-0)

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