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Antineoplastic effects of Dichloroacetate sodium (DCA) and omeprazole (OMP) in canine oral malignant melanoma cell lines: a study of the mechanisms of action

Grant number: 18/16515-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): December 01, 2018
Effective date (End): December 31, 2021
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Maria Lucia Zaidan Dagli
Grantee:Gabriela Fernandes de Toledo
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Sodium dichloroacetate (DCA) and omeprazole (OMP) are two drugs that have been highlighted in recent decades for having promising antineoplastic effects in the treatment of various types of cancers in humans and animals. In previous studies conducted in this laboratory, the treatment of canine oral melanoma cell lines with DCA and OMP not only showed tumor cell inhibitory effects, but when used in combination, presented a synergistic effect. The mechanism of action and subcellular events have not yet been well elucidated in the veterinary literature, and studies of the use of these two drugs in canine cell tumor cell lines are still quite scarce. This project aims to deepen the investigation of the effects of the treatment of 3 strainsmelanoma cells, being one of them human, and thus, to elucidate a little more the metabolic alterations that these two drugs present individually or in association on these cell lines.

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DO NASCIMENTO, RODRIGO S.; NAGAMINE, MARCIA K.; DE TOLEDO, GABRIELA F.; CHAIBLE, LUCAS M.; TEDARDI, V, MARCELLO; DEL-GRANDE, MURILO P.; DA FONSECA, IVONE I. M.; DAGLI, MARIA L. Z.. Sodium dichloroacetate attenuates the growth of B16-F10 melanoma in vitro and in vivo: an opportunity for drug repurposing. ANTI-CANCER DRUGS, v. 32, n. 2, p. 111-116, . (16/20479-7, 17/12855-1, 14/04819-7, 15/01836-0, 18/16515-3)
TOLEDO, GABRIELA F.; NAGAMINE, MARCIA K.; NOWOSH, VICTOR; MACHADO, FELIPPE T.; MASSOCO, CRISTINA O.; SOUZA-PINTO, NADJA C.; DAGLI, MARIA L. Z.. Antineoplastic effects of sodium dichloroacetate and omeprazole, alone or in combination, on canine oral mucosal melanoma cells. FRONTIERS IN VETERINARY SCIENCE, v. 10, p. 11-pg., . (14/04819-7, 17/04372-0, 18/16515-3)
SATO, AYAMI; DA FONSECA, IVONE IZABEL MACKOWIAK; NAGAMINE, MARCIA KAZUMI; DE TOLEDO, GABRIELA FERNANDES; OLIO, RENNAN; HERNANDEZ-BLAZQUEZ, FRANCISCO JAVIER; YANO, TOMOHIRO; YEH, ELIZABETH SHINMAY; DAGLI, MARIA LUCIA ZAIDAN. Effects of Alpha-Connexin Carboxyl-Terminal Peptide (aCT1) and Bowman-Birk Protease Inhibitor (BBI) on Canine Oral Mucosal Melanoma (OMM) Cells. FRONTIERS IN VETERINARY SCIENCE, v. 8, . (16/20479-7, 18/11202-7, 17/12855-1, 18/16515-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
TOLEDO, Gabriela Fernandes de. Antineoplastic effects of dichloroacetate sodium and omeprazole in canine oral melanoma cell lines: a study of the mechanisms of action. 2023. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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