Takayasu's arteritis (TA) is a primary systemic vasculitis that affects large vessels and their main branches. It mainly affects young women. Blood vessel inflammation may result in stenosis, occlusions, ectasias and/or aneurysms and, consequently, difference of blood pressure between limbs and vascular claudication.Aerobic capacity (CA) is the measure of oxygen uptake, transport and use by the body, characterizing the individual's ability to perform activity. It is also a tool that can predict cardiovascular diseases.Our group was a pioneer in demonstrating that AC is decreased in a small, homogeneous sample of young women with TA disease remission. In addition, the safety and efficacy of aerobic exercises in this sample of patients was shown, as well as the influence of these sessions on the pro-inflammatory and angiogenic serum cytokine behavior. However, due to a small and homogeneous sample, it was not possible to correlate CA with clinical and laboratory parameters and also with the presence, location and extent of vascular damage, which are frequently found in patients with to TA.Moreover, to date, no studies have evaluated safety and impact of a strength exercise session in TA. However, strength exercise session shows health benefits of patients with cardiovascular disease and peripheral arterial disease.Therefore, the objective of the present study is to evaluate in a representative sample of both genders and with the disease in different stages of activity: a) the CA; b) impact and safety of the strength exercise session; c) correlation between AC, as well as strength exercise session, with demographic, clinical, therapeutic, comorbid parameters, and presence, location and degree of vascular damage; d) serum cytokine behavior (pro-inflammatory and angiogenic/anti-angiogenic).
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