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Impact of tumor-stroma ratio in oral squamous cell carcinoma prognosis

Grant number: 18/16754-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2018
Effective date (End): October 31, 2020
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Ricardo Della Coletta
Grantee:Karen Yumie Mendonça Miwa
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


Oral cancer, mainly represented by the squamous cell carcinoma (OSCC), is globally the 10th most prevalent cancer worldwide, with a global annual incidence of approximately 300,000 new cases. Despite advances in the diagnosis and treatment options, the prognosis of patients with OSCC has remained virtually unchanged over recent decades, remaining at 50% over 5 years. Therefore, the identification of factors (novel biomarkers) that better represent the biological behavior of the tumor cells is necessary to improve the treatment and prognosis of patients with this tumor. In the last years, by setting international multicenter collaborations, we have conducted a series of studies searching for histopathological markers that can differentiate tumors that show a more aggressive behavior. Besides the new scoring system for OSCC histological grading denominated BD system, which is based on the presence of tumor cell nests (buds) in the invasive front (B = budding) and on depth of invasion (D = depth of invasion), we have recently revealed that tumor-stroma ratio (TSR), within the concept of a simple histological marker, is associated with an unfavorable prognosis for patients with OSCC at early stage. This study also showed that the association of TSR and BD scores improves the prognostic discrimination ability compared with them isolately. Although TSR was associated with cancers from other locations, only one study explored this prognostic marker in OSCCs. The aim of this study is to evaluate the prognostic value of TSR in a series of 150 OSCCs of patients diagnosed and treated in 2 reference Hospitals. This sample will be also scored with BD system and combined analysis (TSR and BD) will be performed. Scoring will be independently carried out by 3 calibrated observers, allowing subsequent determination of intra- and inter-observer degree of agreement. Correlations between TSR and clinic pathological parameters, including BD system, and survival will be performed. The results of this study can confirm the prognostic value of TSR, validating it as a novel prognostic tool for OSCCs.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOURADO, MAURICIO R.; MIWA, KAREN Y. M.; HAMADA, GUILHERME B.; PARANAIBA, LIVIA M. R.; SAWAZAKI-CALONE, IRIS; DOMINGUETI, CATHERINE B.; DE OLIVEIRA, CARINE ERVOLINO; FURLAN, EMYLLE C. B.; LONGO, BRUNA C.; ALMANGUSH, ALHADI; et al. Prognostication for oral squamous cell carcinoma patients based on the tumour-stroma ratio and tumour budding. Histopathology, v. 76, n. 6, . (17/26764-8, 18/16077-6, 18/16754-8, 18/17689-5)
DOMINGUETI, CATHERINE BUENO; MIWA, KAREN YUMIE MENDONCA; DOURADO, MAURICIO ROCHA; SAWAZAKI-CALONE, IRIS; SALO, TUULA A.; PARANAIBA, LIVIA MARIS RIBEIRO; COLETTA, RICARDO D.. Prognostication for oral carcinomas based on two histological scoring systems (BD and iBD models). ORAL DISEASES, v. 27, n. 4, . (17/26764-8, 18/16077-6, 18/16754-8)

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