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Evaluation of avian infection (Gallus gallus domesticus) by Salmonella enteritidis, Salmonella typhimurium and Salmonella heidelberg containing deletion of the ttrA and pduA genet

Grant number: 18/21301-2
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): December 01, 2018
Status:Discontinued
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
Principal researcher:Angelo Berchieri Junior
Grantee:Mauro de Mesquita Souza Saraiva
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated research grant:18/03189-0 - Evaluation of avian infection (Gallus gallus domesticus) by Salmonella enteritidis, Salmonella typhimurium and Salmonella heidelberg containing deletion of the ttrA and pduA genes, AP.TEM
Associated scholarship(s):20/07541-0 - Influence of Salmonella enteritidis and Salmonella typhimurium under gut microbiome from broilers, after deletion of pduA and ttrA genes: a genomic approach, BE.EP.PD

Abstract

Assays done in mammals has shown that enteric salmonellas are able to use the inflammatory process provoked by them as a source of energy to survive and multiply inside the gut. This process is associated with the use of tetrathionate (ttr) as a by-product of the host inflammatory gut response. After the production of tetrathionate it becomes possible to use propanediol (pdu) as an energy source. Therefore, the intestinal inflammatory response of the host promotes efficient bacterial multiplication in the intestinal lumen, with consequent colonization and fecal-oral transmission. Poultry products have been associated with human foodborne diseases. Most of them caused by Salmonella enteritidis (SE) and Salmonella typhimurium (ST). In the last years, the European Community has rejected several poultry products from Brazil because they were contaminated by Salmonella heidelberg (SH). In view of the importance of poultry foods in foodborne salmonellosis we will investigate the relevance of genes related to tetrathionate and ethanolamine metabolism to the intestinal colonization of Salmonella in chickens. It is proposed the construction of mutant strains of SE, ST and SH containing deletions in the genes ttrA and pduA, to assess their behaviour during the infection. The knowledge acquired may help to better understand the relationship between the bacteria and the host, contributing to a better understanding of bacterial behaviour and the search for alternatives to inhibit intestinal survival and colonization.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOUZA SARAIVA, MAURO DE MESQUITA; LIM, KELVIN; MARINHO DO MONTE, DANIEL FARIAS; NAVES GIVISIEZ, PATRICIA EMILIA; RODRIGUES ALVES, LUCAS BOCCHINI; DE FREITAS NETO, OLIVEIRO CAETANO; KARIUKI, SAMUEL; BERCHIERI JUNIOR, ANGELO; BRUNO DE OLIVEIRA, CELSO JOSE; GEBREYES, WONDWOSSEN ABEBE. Antimicrobial resistance in the globalized food chain: a One Health perspective applied to the poultry industry. Brazilian Journal of Microbiology, NOV 2021. Web of Science Citations: 0.
SARAIVA, M. M. S.; RODRIGUES ALVES, L. B.; MONTE, D. F. M.; FERREIRA, T. S.; BENEVIDES, V. P.; BARBOSA, F. O.; FREITAS NETO, O. C.; ALMEIDA, A. M.; BARROW, P. A.; BERCHIERI JUNIOR, A. Deciphering the role of ttrA and pduA genes for Salmonella enterica serovars in a chicken infection model. AVIAN PATHOLOGY, v. 50, n. 3, p. 257-268, MAY 4 2021. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.