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HMutSB immunoexpression in salivary gland tumors

Grant number: 18/12435-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2018
Effective date (End): October 31, 2019
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Pablo Agustin Vargas
Grantee:Laryssa Moura Dias
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


Salivary gland tumors are a heterogeneous group of lesions subdivided into benign and malignant lesions. Pleomorphic Adenoma is the main benign neoplasm of the major and minor salivary glands, as well as the Mucoepidermoid and Cystic Adenoid Carcinomas are the main malignant neoplasms. Recent molecular studies have shown that genetic mutations are one of the major mechanisms associated with the development of these lesions. The Mismatch System represents an important mechanism of repair of mismatch bases and deletions or insertions of DNA sequences, avoiding the occurrence of changes that allow the development of mutations. This system consists in groups of heterodimer proteins that act in the identification and removal of errors. The hMSH2 and hMSH3 proteins are constituents of the hMutS² group, responsible for the identification of DNA insertion and deletion loops, as well as 2 or more mismatched base sequences. Studies have shown that altered immunohistochemical expressions of these proteins are associated with the development and progression of various human diseases. However, these expressions in salivary gland tumors have not yet been thoroughly explored. This work aims to analyze the immunohistochemical expressions of hMSH2 and, for the first time, hMSH3 in 30 cases of pleomorphic adenomas, 15 mucoepidermoid carcinomas and 15 cystic adenoid carcinomas, comparing their results with 10 samples of normal minor salivary glands excised together with mucoceles. The results will be correlated with the specific histopathological characteristics and prognosis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DO AMARAL-SILVA, GLEYSON KLEBER; DIAS, LARYSSA MOURA; LINHARES ALMEIDA MARIZ, BRUNO AUGUSTO; FONSECA, FELIPE PAIVA; CARRINHO AYROZA RANGEL, ANA LUCIA; ZANELLA, VIRGILIO GONZALES; CASTILHO, ROGERIO MORAES; MARTINS, MANOELA DOMINGUES; VARGAS, PABLO AGUSTIN; WAGNER, VIVIAN PETERSEN. MutS alpha expression predicts a lower disease-free survival in malignant salivary gland tumors: an immunohistochemical study. MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL, v. 27, n. 2, p. 10-pg., . (09/53839-2, 17/08995-2, 18/12435-5, 15/21520-8, 16/21785-4, 18/24715-2)

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