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"Genotyping of Trypanosoma cruzi in samples from patients with Chronic Chagas' Heart Disease''

Grant number: 18/22093-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): December 01, 2018
Effective date (End): January 31, 2023
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:José Antonio Marin-Neto
Grantee:Maykon Tavares de Oliveira
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:16/25403-9 - Investigations on the pathogenesis, pathophysiology and therapy in humans and in an experimental model with the chronic cardiomyopathy of Chagas Disease, AP.TEM
Associated scholarship(s):19/11943-0 - Genotyping of Trypanosoma cruzi in samples of immigrant patients living in Europe: correlation between Trypanosoma cruzi molecular epidemiology and the different clinical forms of Chagas Disease in the European continent, BE.EP.PD


Trypanosoma cruzi has a structure that allows subdivision into six distinct genetic groups, called TcI to TcVI, with differences in terms of geographical distribution, biological properties and susceptibility to drugs. The correlation between parasitic genetic variability and clinical forms of Chagas disease (ChD) remains incompletely established. The predominance of DTUs (Genetic Groups) TcII and TcVI in several Brazilian regions, associated to both the domestic and wild cycle of ChD is well known. This project intends to verify the genotypes of the parasites present in 100 patients with ChD enrolled in Ribeirão Preto and to evaluate the existence of potential targets in the parasite genome in order to correlate the results with the clinical evolution of the patients from whom the parasites were isolated. In addition to genotyping, genomic screening of the parasites, isolated from the patients by blood culture, will be carried out to identify potential target genes, which serve as prognostic markers for human ChD. This objective will be achieved simultaneously to achieve the primary goal, that is, to equip the laboratory headed by Professor João Santana da Silva, researcher supervisor of the works referred to in this subproject, Department of Biochemistry and Immunology, FMRP- USP, of genotyping capability of T. cruzi for further use in other clinical application projects.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA, MAYKON TAVARES; SCHMIDT, ANDRE; DA SILVA, MARIA CLAUDIA; DONADI, EDUARDO ANTONIO; DA SILVA, JOAO SANTANA; MARIN-NETO, JOSE ANTONIO. Parasitic Load Correlates With Left Ventricular Dysfunction in Patients With Chronic Chagas Cardiomyopathy. FRONTIERS IN CARDIOVASCULAR MEDICINE, v. 8, . (18/22093-4, 16/25403-9)
DE OLIVEIRA, MAYKON TAVARES; SULLEIRO, ELENA; DA SILVA, MARIA CLAUDIA; SILGADO, AROA; DE LANA, MARTA; DA SILVA, JOAO SANTANA; MOLINA, ISRAEL; ANTONIO MARIN-NETO, J.. Intra-Discrete Typing Unit TcV Genetic Variability of Trypanosoma cruzi in Chronic Chagas' Disease Bolivian Immigrant Patients in Barcelona, Spain. FRONTIERS IN CARDIOVASCULAR MEDICINE, v. 8, . (16/25403-9, 18/22093-4, 19/11943-0)

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