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Effect of protease-activated receptor type 1 (PAR1) activation on the osteogenic activity in human periodontal ligament stem cells membranes: an in vivo study

Grant number: 18/13818-5
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): October 01, 2018
Effective date (End): January 31, 2020
Field of knowledge:Health Sciences - Dentistry - Periodontology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Marinella Holzhausen Caldeira
Grantee:Tomaz Alves da Silva Neto
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The regeneration of periodontal tissues lost through periodontal disease has been sought through biological solutions since the current therapeutic alternatives available are not completely predictable and satisfactory. Periodontal ligament stem cells (PDLSCs) are able to differentiate into cementoblasts/osteoblasts, adipocytes and collagen-forming cells, contributing to periodontal tissue regeneration. This way, cellsheets have attracted extensive attention for their repair/regeneration properties of periodontal defects because they are capable of allowing osteoblastic proliferation and supporting the formation of mineralized matrix. Recently, our group has observed that activation of the protease-activated receptor type 1 (PAR1) is able to increase the osteogenic activity of the PDLSCs. The purpose of the present study is to evaluate the osteogenic potential of cell membranes of PDLSCs carried with the activating peptide of PAR1 in vivo.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARLUS DA SILVA PEDROSA; TOMAZ ALVES; FERNANDO NEVES NOGUEIRA; MARINELLA HOLZHAUSEN; CARLA RENATA SIPERT. Cytotoxicity and cytokine production by calcium silicate-based materials on periodontal ligament stem cells. Brazilian Dental Journal, v. 32, n. 3, p. 65-74, . (16/13944-5, 18/13818-5, 17/23158-0)
EMANUEL SILVA ROVAI; TOMAZ ALVES; LETÍCIA MIQUELITTO GASPARONI; BRUNO NUNES DE FRANÇA; CARLA RENATA SIPERT; ALPDOGAN KANTARCI; MARINELLA HOLZHAUSEN. Protease-activated receptor type 1 (PAR1) increases CEMP1 gene expression through MAPK/ERK pathway. Brazilian Oral Research, v. 36, . (18/13818-5, 17/23158-0)
ROVAI, EMANUEL S.; ALVES, TOMAZ; HOLZHAUSEN, MARINELLA. Protease-activated receptor 1 as a potential therapeutic target for COVID-19. Experimental Biology and Medicine, v. 246, n. 6, p. 688-694, . (17/23158-0, 18/13818-5, 19/14846-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA NETO, Tomaz Alves da. Insights from in vitro and in vivo studies evaluating the Protease Activated Receptor 1 (PAR1) potential pathways and associated osteogenic outcomes. 2020. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Odontologia (FO/SDO) São Paulo.

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