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Salivary cytokine profile of children from aggressive periodontitis families

Grant number: 18/12335-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2018
Effective date (End): December 31, 2019
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Renato Corrêa Viana Casarin
Grantee:Larissa Bizarre
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


Aggressive periodontitis is a relatively rare, rapidly progressing disease affecting adolescents and young adults. It causes rapid vertical loss of the supporting alveolar bone, resulting in the appearance of generally deep infra-bony pouches. The etiology is related to a group of bacteria of high virulence besides genetic compromise in certain families, increasing the occurrence of the disease in descendants of affected individuals. Studies involving children of PAG individuals were performed and identified early clinical and microbiological changes in these individuals suggesting the presence of factors that would favor the development of the disease. Therefore, the present study aims to analyze the inflammatory pattern of saliva in children aged 6 to 12 years from parents with generalized aggressive periodontitis (n=20) and children from parent with periodontal health (n=20), evaluating the salivary pattern of the inflammatory response, in an age and gender matched study. Data from the enzyme-linked immunoassay will be compared using the Shapiro-Wilk test to verify the normality of the data. If the data were normal, the comparison of the levels of cytokines (IL-1beta, IFN-gamma, IL-10, IL-4, IL-17 e TNF-alpha) between the groups will be performed through the t-Student test. If the data are not normal, the Mann-Whitney test will be used to compare the levels between the two groups. All tests will be performed considering a significance level of 5%.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MONTEIRO, MABELLE FREITAS; DE SOUSA PAZ, HELVIS ENRI; BIZARRE, LARISSA; BONILHA, GABRIELA MARTIN; CASATI, MARCIO ZAFFALON; VIANA CASARIN, RENATO CORREA. Salivary IL-4: A Bleeding Predictor on Probing in Descendants of Severe Periodontitis Patients. Journal of Clinical Pediatric Dentistry, v. 46, n. 2, p. 5-pg., . (15/50264-0, 18/12335-0)

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