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Evaluation of poloxamer-based ropivacaine gel formulations in a post operative pain model

Grant number: 18/12870-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2018
Effective date (End): July 31, 2019
Field of knowledge:Biological Sciences - Pharmacology - Clinical Pharmacology
Principal Investigator:Giovana Tofoli Moniz
Grantee:Beatriz Furlan
Host Institution: Centro de Pesquisas Odontológicas São Leopoldo Mandic. Faculdade São Leopoldo Mandic (SLMANDIC). Sociedade Regional de Ensino e Saúde S/S Ltda (SRES). Campinas , SP, Brazil
Associated research grant:14/14457-5 - Lipid-based nanocarriers (SLN/NLC and remote-loading liposomes) used to improve the upload and potency of local anesthetics, AP.TEM


In the last decades the development of drug-delivery systems, such as thermoreversible gels made it possible to manipulate some biopharmaceutical and pharmacological properties of drugs, improving their therapeutic effects (long duration of action associated to low systemic toxicity) and their clinical use. Local anesthtetics, such as ropivacaine, are widely used in clinical medicine. However, these drugs can induce convulsions and arrhythmia due to sodium channels blockade. The use of poloxamers to form thermoreversible gels, would be interesting due to its capacity of improve the pharmacological properties of this local anesthetic and the possibility of alterations in the posology of this drug, being potentially advantageous for the pain relief. Thus, the aim of this study is to evaluate ropivacaine associated with poloxamers in a post-operative pain model in rats. (AU)

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