Advanced search
Start date

Influence of electric stimulation on palatal wound healing: randomized clinical trial

Grant number: 18/03353-5
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): October 01, 2018
Effective date (End): December 31, 2019
Field of knowledge:Health Sciences - Dentistry - Periodontology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Mauro Pedrine Santamaria
Grantee:Manuela Maria Viana Miguel
Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil


The repair is characterized as a fundamental mechanism for tissue maintenance, with the presence of a cascade of cellular and molecular events that associate the recovery of the injured areas. Surgical periodontal procedures may lead to the execution of wounds in the palate region for example, to harvest free gingival graft with the goals to root coverage, ridge preservation and accuracy of soft tissue defects around implants. However, it has been reported that this approach can cause some degree of morbidity and discomfort in the handled tissue to the patient. Therefore, a treatment for the palatine area is searched to help healing the wounds in the donor area. Many strategies have been used in an attempt to accelerate healing, one is the application of an exogenous electrical stimulation to activate tissue repair. The objective of this study is to clinically evaluate the 3-month outcome the of electrical stimulation onpalatal wounds. For this, a controlled clinical trial will be carried out following the CONSORT STATEMENT 2010. Forty-four patients in need of ridge preservation will be randomly divided in 2 groups: SHAM - Free gingival graft and sham electrical stimulation onthe palatal open wound ; TEST - Free gingival graft and electric electrical stimulation on the open palatal wound. An alternating current of 100 ¼A will be used at 9 kHz. The application of the electrical stimulus will be given for 120 seconds, once a day for 5 days. Clinical perceptions will be evaluated by means of the remaining wound area, tissue thickness, scar and colorimetry tissue, re-epithelialization, early-wound healing index. In addition,patient-related perceptions will be evaluated by post- operative discomfort, number of analgesic pills used, tissue edema and Oral Health-related Quality of Life. These parameters will be assessed at baseline andafter 7, 14, 21, 30, 45 e 90 the procedure.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIANA MIGUEL, MANUELA MARIA; MATHIAS-SANTAMARIA, INGRID FERNANDES; ROSSATO, AMANDA; FERREIRA FERRAZ, LAIS FERNANDA; FIGUEIREDO-NETO, ANTONIO MARTINS; DE MARCO, ANDREA CARVALHO; VIANA CASARIN, RENATO CORREA; WALLET, SHANNON MARGARET; TATAKIS, DIMITRIS N.; MATHIAS, MARCIO ANTONIO; et al. Microcurrent electrotherapy improves palatal wound healing: Randomized clinical trial. Journal of Periodontology, v. 92, n. 2, . (18/03353-5, 18/07340-5, 16/16102-5, 16/07528-9, 16/24531-3, 14/50983-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MIGUEL, Manuela Maria Viana. Influence of electric stimulation and enamel matrix protein derivative application on palatal wound healing: two randomized clinical trials. 2019. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Ciência e Tecnologia. São José dos Campos São José dos Campos.

Please report errors in scientific publications list by writing to: