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Development of pharmaceutical formulation for burns' healing

Grant number: 18/06475-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2018
Effective date (End): December 31, 2023
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Priscila Gava Mazzola
Grantee:Janaína Artem Ataide
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):21/12452-0 - Mixed dendrimer micelles for siRNA and rifamycin SV co-delivery in tumor cells, BE.EP.DR

Abstract

Burns are among the most common types of tissue lesions in society, and can have several causes, such as physical, chemical, thermal and electrical agents. These lesions have varying levels of tissue loss, leading to impairment of skin's functional integrity. Clinically, burns are classified in first, second and third degree lesions, according to the depth of tissue involvement. In Brazil, they are among the main external causes of death recorded, and this mortality is mainly related to infections that progress with Septicemia. The adequate management of these lesions, mainly with the use of topical antimicrobial therapy, is of fundamental importance to avoid complications and to improve the survival of these patients. In this context, the development of efficient drug delivery systems can improve existing treatments, increasing actives applicability. Together with antimicrobial properties, these formulations should take into account pain relief and functional and aesthetic effects, enhancing patient comfort. Therefore, the present project intends to develop a topical pharmaceutical product for use in burns, aiming at prevention and treatment of microbiological contaminations, pain relief and a more efficient healing with better aesthetic effect. For this, nanoparticulate delivery systems will be developed and incorporated into topical formulations that are more convenient and comfortable for patients, such as suspensions and gels. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GIAROLA, LEILA REGINA; COCO, JULIA CEDRAN; SOUSA, ILZA MARIA DE OLIVEIRA; CEFAL, LETICIA CARAMORI; ATAIDE, JANAINA ARTEM; TAVARES, GUILHERME DINIZ; RODRIGUES, RODNEY ALEXANDRE FERREIRA; FOGLIO, MARY ANN; MAZZOLA, PRISCILA GAVA. Pterodon pubescens Benth (sucupira) microencapsulation influence on formulation stability outcome compared to non-encapsulated extract. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 67, p. 13-pg., . (18/07707-6, 16/03444-5, 15/09293-6, 18/06475-4, 13/06384-5)
COCO, JULIA CEDRAN; ATAIDE, JANAINA ARTEM; SAKE, JOHANNES A.; TAMBOURGI, ELIAS BASILE; EHRHARDT, CARSTEN; MAZZOLA, PRISCILA GAVA. In vitro antioxidant and wound healing properties of baru nut extract (Dipteryx alata Vog.) in pulmonary epithelial cells for therapeutic application in chronic pulmonary obstructive disease (COPD). NATURAL PRODUCT RESEARCH, . (18/17451-9, 18/06475-4, 18/06043-7)
D'ANGELO, NATALIA A.; NORONHA, MARIANA A.; KURNIK, ISABELLE S.; CAMARA, MAYRA C. C.; VIEIRA, JORGE M.; ABRUNHOSA, LUIS; MARTINS, JOANA T.; ALVES, THAIS F. R.; TUNDISI, LOUISE L.; ATAIDE, JANAINA A.; et al. Curcumin encapsulation in nanostructures for cancer therapy: A 10-year overview. International Journal of Pharmaceutics, v. 604, . (18/10799-0, 18/07707-6, 18/06475-4, 17/10789-1, 19/08549-8, 20/03727-2)
SILVERIO, LUIZA APARECIDA LUNA; COCO, JULIA CEDRAN; DE MACEDO, LUCAS MALVEZZI; DOS SANTOS, ERICA MENDES; SUEIRO, ANA CLAUDIA; ATAIDE, JANAINA ARTEM; TAVARES, GUILHERME DINIZ; PAIVA-SANTOS, ANA CLAUDIA; MAZZOLA, PRISCILA GAVA. Natural product-based excipients for topical green formulations. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 33, p. 18-pg., . (18/06475-4, 18/07707-6, 21/00319-3, 20/11333-4)
TUNDISI, LOUISE LACALENDOLA; ATAIDE, JANAINA ARTEM; DA FONSECA, JESSICA HELINE LOPES; SILVERIO, LUIZA APARECIDA LUNA; LANCELLOTTI, MARCELO; PAIVA-SANTOS, ANA CLAUDIA; D'AVILA, MARCOS AKIRA; KOHANE, DANIEL S.; MAZZOLA, PRISCILA GAVA. Terbinafine Nanohybrid: Proposing a Hydrogel Carrying Nanoparticles for Topical Release. PHARMACEUTICS, v. 15, n. 3, p. 16-pg., . (18/06475-4, 17/10728-2, 18/07707-6, 18/05421-8)
TUNDISI, LOUISE LACALENDOLA; ATAIDE, JANAINA ARTEM; COSTA, JULIANA SOUZA RIBEIRO; COELHO, DIEGO DE FREITAS; LISZBINSKI, RAQUEL BESTER; LOPES, ANDRE MORENI; OLIVEIRA-NASCIMENTO, LAURA; BISPO DE JESUS, MARCELO; JOZALA, ANGELA FAUSTINO; EHRHARDT, CARSTEN; et al. Nanotechnology as a tool to overcome macromolecules delivery issues. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 222, p. 16-pg., . (18/06475-4, 18/10799-0, 19/06023-9, 17/10789-1, 17/10728-2, 18/07707-6)
SUEIRO, ANA CLAUDIA; DOS SANTOS, ERICA MENDES; TUNDISI, LOUISE LACALENDOLA; MASQUETTI FAVA, ANA LAURA; LUNA SILVERIO, LUIZA APARECIDA; COCO, JULIA CEDRAN; ATAIDE, JANAINA ARTEM; PAIVA-SANTOS, ANA CLAUDIA; MAZZOLA, PRISCILA GAVA. Transdermal delivery systems for migraine treatment: A gap to explore. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 77, p. 8-pg., . (18/06475-4, 18/07707-6, 21/00319-3, 20/11333-4)
DE MACEDO, LUCAS MALVEZZI; DOS SANTOS, ERICA MENDES; ATAIDE, JANAINA ARTEM; DE SOUZA E SILVA, GABRIELA TRINDADE; DE OLIVEIRA GUARNIERI, JOAO PAULO; LANCELLOTTI, MARCELO; JOZALA, ANGELA FAUSTINO; PIRES ROSA, PAULO CESAR; MAZZOLA, PRISCILA GAVA. Development and Evaluation of an Antimicrobial Formulation Containing Rosmarinus officinalis. Molecules, v. 27, n. 16, p. 15-pg., . (18/07707-6, 20/11333-4, 18/06475-4)
DE CASTRO, KARINE CAPPUCCIO; COCO, JULIA CEDRAN; DOS SANTOS, ERICA MENDES; ATAIDE, JANAINA ARTEM; MARTINEZ, RENATA MILIANI; MONTEIRO DO NASCIMENTO, MONICA HELENA; PRATA, JOAO; LOPES DA FONTE, PEDRO RICARDO MARTINS; SEVERINO, PATRICIA; MAZZOLA, PRISCILA GAVA; et al. Pluronic (R) triblock copolymer-based nanoformulations for cancer therapy: A 10-year overview. JOURNAL OF CONTROLLED RELEASE, v. 353, p. 21-pg., . (18/10799-0, 20/03727-2, 21/00319-3, 19/20303-4, 20/11333-4, 18/06475-4, 19/16169-0, 18/07707-6, 17/10789-1, 19/08549-8)
DOS SANTOS, ERICA MENDES; ATAIDE, JANAINA ARTEM; COCO, JULIA CEDRAN; MASQUETTI FAVA, ANA LAURA; LUNA SILVERIO, LUIZA APARECIDA; SUEIRO, ANA CLAUDIA; ALVES SILVA, JESSICA RIBEIRO; LOPES, ANDRE MORENI; PAIVA-SANTOS, ANA CLAUDIA; MAZZOLA, PRISCILA GAVA. Spondias sp: Shedding Light on Its Vast Pharmaceutical Potential. Molecules, v. 28, n. 4, p. 16-pg., . (20/11333-4, 18/07707-6, 21/00319-3, 18/10799-0, 18/06475-4, 17/10789-1)

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