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Influence of protein corona on interaction and internalization of silica nanoparticles in human cells: from two-dimensional to tri-dimensional images

Grant number: 18/09555-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2018
Effective date (End): January 31, 2023
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Mateus Borba Cardoso
Grantee:Flávia Elisa Galdino
Host Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia e Inovação (Brasil). Campinas , SP, Brazil
Associated research grant:15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles, AP.TEM

Abstract

Protein corona is a phenomenon characterized by the spontaneous and nonspecific adsorption of proteins on nanoparticles' surface. This protein shell influences on the biological function of nanoparticles applied in Nanomedicine. Within this context, zwitterionic groups are among the compounds used to supress the protein corona formation. Nevertheless, in order to apply these nanoparticles to therapies and diagnostics, it is necessary to get a deeply knowledge about the interaction and internalization of them into cells. Considering these facts, this project's motivation is to study the interaction and internalization of silica nanoparticles (SiO2NPs) by human cells. For this, nanoparticles that induce the formation of protein corona and nanoparticles functionalized with zwitterionic compounds (absence of protein corona) will be analyzed. Among the studies to be performed in this project, the highlight is a detailed thickness and morphology protein corona characterization carry out by cryo-electron transmission microscopy. Moreover, transmission microscopy and X-ray tomography will allow to get a complete and fundamental view of the internalization process and localization of nanoparticles in human cells either in 2-D and in 3-D, respectively. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOUSA RIBEIRO, IRIS RENATA; GALDINO, FLAVIA ELISA; SILVEIRA, CAMILA PEDROSO; CARDOSO, MATEUS BORBA. Precision medicine based on nanoparticles: the paradigm between targeting and colloidal stability. Nanomedicine, v. 16, n. 17, p. 6-pg., . (15/25406-5, 17/21318-0, 19/14007-3, 18/09555-9)
FERREIRA, LARISSA FERNANDA; PICCO, AGUSTIN SILVIO; GALDINO, FLAVIA ELISA; CALUMBY ALBUQUERQUE, LINDOMAR JOSE; BERRET, JEAN-FRANCOIS; CARDOSO, MATEUS BORBA. Nanoparticle-Protein Interaction: Demystifying the Correlation between Protein Corona and Aggregation Phenomena. ACS APPLIED MATERIALS & INTERFACES, v. 14, n. 25, p. 11-pg., . (17/02145-7, 18/09555-9, 21/12071-6, 20/00767-3, 14/21910-8, 19/24894-7, 15/25406-5)
RIBEIRO, I. R. S.; DA SILVA, R. F.; SILVEIRA, C. P.; GALDINO, F. E.; CARDOSO, M. B.. Nano-targeting lessons from the SARS-CoV-2. NANO TODAY, v. 36, p. 4-pg., . (15/25406-5, 18/09555-9, 19/14007-3)
GALDINO, FLAVIA E.; PICCO, AGUSTIN S.; CAPELETTI, LARISSA B.; BETTINI, JEFFERSON; CARDOSO, MATEUS B.. Inside the Protein Corona: From Binding Parameters to Unstained Hard and Soft Coronas Visualization. Nano Letters, v. 21, n. 19, p. 8250-8257, . (18/09555-9, 15/25406-5, 14/21910-8)
SILVEIRA, CAMILA PEDROSO; SCHNEID, ANDRESSA DA CRUZ; RIBEIRO, IRIS RENATA SOUSA; GALDINO, FLAVIA ELISA; CARDOSO, MATEUS BORBA. A nano perspective behind the COVID-19 pandemic. NANOSCALE HORIZONS, v. 6, n. 11, . (19/14007-3, 15/25406-5, 18/00763-8, 17/21318-0, 18/09555-9)
CAPELETTI, LARISSA BRENTANO; AFFONSO DE OLIVEIRA, JESSICA FERNANDO; DIAS LOIOLA, LIVIA MESQUITA; GALDINO, FLAVIA ELISA; DA SILVA SANTOS, DENYS EWERTON; SOARES, THEREZA AMELIA; FREITAS, RAUL DE OLIVEIRA; CARDOSO, MATEUS BORBA. Gram-Negative Bacteria Targeting Mediated by Carbohydrate-Carbohydrate Interactions Induced by Surface-Modified Nanoparticles. ADVANCED FUNCTIONAL MATERIALS, v. 29, n. 48, . (17/01167-7, 13/22429-9, 15/25406-5, 18/09555-9, 16/21598-0)
SCHNEID, ANDRESSA C.; RIBEIRO, IRIS R. S.; GALDINO, FLAVIA E.; BETTINI, JEFFERSON; CARDOSO, MATEUS B.. Degradable and colloidally stable zwitterionic-functionalized silica nanoparticles. Nanomedicine, . (17/21318-0, 18/09555-9, 18/00763-8, 15/25406-5)
SCHNEID, ANDRESSA DA CRUZ; SILVEIRA, CAMILA PEDROSO; GALDINO, FLAVIA ELISA; FERREIRA, LARISSA FERNANDA; BOUCHMELLA, KARIM; CARDOSO, MATEUS BORBA. Colloidal Stability and Redispersibility of Mesoporous Silica Nanoparticles in Biological Media. Langmuir, v. 36, n. 39, p. 11442-11449, . (19/14007-3, 18/00763-8, 15/25406-5, 18/09555-9, 17/02145-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GALDINO, Flávia Elisa. Characterization of protein corona and its effect on cell internalization of silica nanoparticles. 2023. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.

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