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Cross-talk between gonadal gonadotropin-inhibitory hormone (GnIH) and thyroid hormones (THs) in the hypothalamic-pituitary-peripheral axis of zebrafish (Danio rerio)

Grant number: 18/15319-6
Support Opportunities:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): October 29, 2018
Effective date (End): April 28, 2019
Field of knowledge:Agronomical Sciences - Fishery Resources and Fishery Engineering - Aquaculture
Principal Investigator:Rafael Henrique Nóbrega
Grantee:Maira da Silva Rodrigues
Supervisor: Hamid Reza Habibi
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Research place: University of Calgary, Canada  
Associated to the scholarship:17/15793-7 - Effects of hypothyroidism on testicular function of Danio rerio and relation between thyroid hormones and follicle stimulating hormone (Fsh), BP.MS


Thyroid hormones (T4/T3) exert several roles on regulating vertebrate homeostasis acting on several physiological processes such as growth, behavior, stress and on the reproductive system. In mammals, the role of thyroid hormones in reproduction has been well investigated, however the interaction between reproduction and thyroid axes is still unknown. This study aims to evaluate the role of thyroid hormones on zebrafish reproduction. To answer this question, a thyroid hormone disruptor, methimazole, will be used to generate a model of thyroid-induced insufficiency. Fish will be exposed to 1 mM of methimazole dissolved into the water for 21 days, after exposure they will be dissected and their testes will be collected for gene expression analyses of important elements of the HPG axis, such as GnRH and GnIH. Testes will then be submitted to an ex vivo organ culture system, in order to study the effects of GnIH and THs on spermatogenesis. We expect to clarify the mechanisms of cross-talk between GnIH and THs in the hypothalamic-pituitary-peripheral axis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FALLAH, HAMIDEH P.; RODRIGUES, MAIRA S.; CORCHUELO, SHERYLL; NOBREGA, RAFAEL H.; HABIBI, HAMID R.. Role of GnRH Isoforms in Paracrine/Autocrine Control of Zebrafish (Danio rerio) Spermatogenesis. Endocrinology, v. 161, n. 2, . (17/15793-7, 18/15319-6)
FALLAH, HAMIDEH P.; RODRIGUES, MAIRA S.; ZANARDINI, MAYA; NOBREGA, RAFAEL H.; HABIBI, HAMID R.. Effects of gonadotropin-inhibitory hormone on early and late stages of spermatogenesis in ex-vivo culture of zebrafish testis. Molecular and Cellular Endocrinology, v. 520, . (17/15793-7, 18/15319-6)
RODRIGUES, MAIRA S.; FALLAH, HAMIDEH P.; ZANARDINI, MAYA; MALAFAIA, GUILHERME; HABIBI, HAMID R.; NOBREGA, RAFAEL H.. Interaction between thyroid hormones and gonadotropin inhibitory hormone in ex vivo culture of zebrafish testis: An approach to study multifactorial control of spermatogenesis. Molecular and Cellular Endocrinology, v. 532, . (17/15793-7, 18/15319-6, 14/07620-7)

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