Advanced search
Start date

Synthesis of bioactive glass coating for titanium surface using the plasma electrolytic oxidation: electrochemical and antimicrobial analysis in a microcosm model

Grant number: 18/04630-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): September 01, 2018
Effective date (End): February 29, 2020
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Valentim Adelino Ricardo Barão
Grantee:Raphael Cavalcante Costa
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


Materials that exhibit antimicrobial and osteogenic properties are promising alternatives to improve the biocompatibility of implants. In this perspective, the aim of this study is to synthetize a bioactive glass (Bioglass-45S5®) for the surface treatment of commercially pure titanium discs (cpTi) using the plasma electrolytic oxidation (PEO), and to evaluate its influence on the physical-chemical, electrochemical and antimicrobial properties of cpTi. CpTi discs (10 × 2mm) will be used: machined (control group) and treated with Bioglass-45S5® (experimental group). The topography of the discs will be characterized by atomic force microscopy (AFM), scanning electron microscopy (SEM), profilometry and surface free energy. The composition and phases of the oxide layer formed on the surface will be evaluated by means of energy dispersive spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction analysis (XRD). Electrochemical tests will be conducted (open circuit potential, electrochemical impedance spectroscopy and potentiodynamic test) to analyze the corrosive behavior of the cpTi. The effect of treatment on bacterial adhesion and biofilm formation on the surface will be tested using multi-species biofilm model of microcosmos, human saliva will be used as bacterial inoculum. In the quantitative analysis of the microbiological data the pH of the biofilm and the levels and proportions of 40 bacterial species will be evaluated by the checkerboard DNA-DNA hybridization technique. SEM and laser confocal microscopy (live and dead) will be used to visualize the formed biofilm. Quantitative data will be submitted to the most appropriate statistical analysis with 5% significance level. The number of specimens for each test will be determined after the pilot study. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COSTA, RAPHAEL C.; SOUZA, JOAO G. S.; CORDEIRO, JAIRO M.; BERTOLINI, MARTINNA; DE AVILA, ERICA D.; LANDERS, RICHARD; RANGEL, ELIDIANE C.; FORTULAN, CARLOS A.; RETAMAL-VALDES, BELEN; DA CRUZ, NILSON C.; et al. Synthesis of bioactive glass-based coating by plasma electrolytic oxidation: Untangling a new deposition pathway toward titanium implant surfaces. Journal of Colloid and Interface Science, v. 579, p. 680-698, . (18/04630-2)
COSTA, RAPHAEL CAVALCANTE; SOUZA, JOAO GABRIEL SILVA; BERTOLINI, MARTINNA; RETAMAL-VALDES, BELEN; FERES, MAGDA; BARAO, VALENTIM A. R.. Extracellular biofilm matrix leads to microbial dysbiosis and reduces biofilm susceptibility to antimicrobials on titanium biomaterial: An in vitro and in situ study. Clinical Oral Implants Research, v. 31, n. 12, p. 1173-1186, . (18/04630-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
COSTA, Raphael Cavalcante. Newly strategies to enhance titanium surface properties and to control biofilm-related peri-implant infections. 2020. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.

Please report errors in scientific publications list by writing to: