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Nickel catalyzed stereoselective C-C coupling reactions: design, evaluation of ligands, and synthetic applications

Grant number: 18/08627-6
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): August 01, 2018
Effective date (End): July 31, 2021
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Carlos Roque Duarte Correia
Grantee:Carson Wanderley Wiethan
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:14/25770-6 - New frontiers in cross-coupling reactions promoted by palladium: combining enantioselective catalysis, C-H activations, new materials and in flux reactions aiming at high efficiency and sustainability in synthetic processes, AP.TEM


Many of the catalytic process currently employed by the industrial sector makes use of rare and expensive metals. However, the replacement of these elements by base metals, such as Fe, Cu Ni, etc, might not be something trivial. In this regard, this research project aims the development of new catalytic systems based on nickel complexes for application in aza- and oxa-Heck-Matsuda couplings, as well as in intermolecular desymmetrization of carbonyl compounds through asymmetric ±-arylation reactions. To this, will be evaluated the synthesis of new N, N and phosphine based ligands, were will be studied the stereoelectronic influences of different groups on the catalytic activity of the metal. After, will be performed the synthesis and the characterization of pre-catalysts based in Ã-aril nickel complexes derived from the ligands synthetized, as well as evaluating synthetic methodologies to improve the performance of the catalyst systems developed in the proposed transformations. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SCARPA DE SOUZA, EDSON LEONARDO; WIETHAN, CARSON; DUARTE CORREIA, CARLOS ROQUE. Iron-Catalyzed Meerwein Carbooxygenation of Electron-Rich Olefins: Studies with Styrenes, Vinyl Pyrrolidinone, and Vinyl Oxazolidinone. ACS OMEGA, v. 4, n. 20, p. 18918-18929, NOV 12 2019. Web of Science Citations: 0.

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