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Spin coating technique applied to the coating of ventricular assist device with nitric oxide releasing polyester films

Grant number: 18/12552-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2018
Effective date (End): May 31, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal researcher:Marcelo Ganzarolli de Oliveira
Grantee:Yasmim Raquel Lopes
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:16/02414-5 - Topical and absorbable biomaterials for the local nitric oxide release, AP.TEM
Associated scholarship(s):19/22827-0 - Gelatin-polycaprolactone nanocomposite for dual nitrix oxide release, BE.EP.IC

Abstract

Polynitrosated polyesters may be used for the surface coating of blood-contacting medical devices, including ventricular assist devices (VAD) and intracoronary stents, in order to reduce their thrombogenicity. The objectives of the present project are: (1) the preparation of blends of polysulfhydrylated polyester (PSPE) with poly(L- lactic acid) (PLLA) and poly(caprolactone) (PCL) by spin coating onto test samples of polyurethane VAD; (2) the S-nitrosation of the coated films onto the test samples, to obtain coatings capable of releasing NO thermally after contact with the aqueous medium and (3) the characterization of the kinetics of NO release form the coated VAD, by chemiluminescence. (AU)

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