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Remodeling of omega 3 and omega 6 polyunsaturated fatty acids in extracellular vesicles released by Melanoma cells: changed response to radiotherapy?

Grant number: 17/02549-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2018
Effective date (End): December 31, 2021
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Roger Chammas
Grantee:Renata Ottes Vasconcelos
Host Institution: Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:14/03742-0 - Nanoparticles that bind to lipoprotein receptors in the treatment atherosclerosis, acute myocardial infarction, post-heart transplantation status, cancer and endometriosis, AP.TEM


Melanoma is considered one of the most aggressive types of Cancer. Its relevance is increasing, as its incidence has increased rapidly around the world and there is still no effective therapy for metastatic disease. The conventional therapies such as chemotherapy and radiotherapy have not been effective in most cases due to intrinsic/extrinsic resistance observed in Melanoma cells. In the last decade, the Extracellular Vesicles (EVs) have attracted much interest as important mediators of intercellular communication, since they are able to modify the tumor microenvironment actively, stimulating tumor progression. In this sense, EVs have been considered as potential sources for the discovery of new biomarkers in Cancer. Recently, a promising tool in research vesicles, and more specifically in Cancer context has emerged, it is lipidomics. Lipidomics addresses not only the lipid profile, but also changes in lipid composition, of complex samples (either cells, tissues or body fluids). Interestingly, EVs from tumor cells are enriched in certain types of lipids in their membranes, including glycosphingolipids, cholesterol, sphingomyelin and phosphatidylserine. No study has evaluated the influence of the presence of omega 3 and omega 6 polyunsaturated fatty acids (omega 3 and omega 6 PUFA) and their incorporation into phospholipids present in the plasma membrane of EVs so far. Thus, the purpose of this project is to investigate the impact of omega 3 PUFA, ±-linolenic, eicosapentaenoic and docosahexaenoic acids, and omega 6 PUFA, linoleic and arachidonic acids incorporated into phospholipids from EVs produced by Melanoma cells during the exposure to ionizing radiation, and thus, evaluate possible changes related to the inflammatory process, and consequently, due to tumor progression. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VASCONCELOS, RENATA OTTES; SERINI, SIMONA; DE SOUZA VOTTO, ANA PAULA; TRINDADE, GILMA SANTOS; FANALI, CATERINA; SGAMBATO, ALESSANDRO; CALVIELLO, GABRIELLA. Combination of omega-3 fatty acids and cisplatin as a potential alternative strategy for personalized therapy of metastatic melanoma: an in-vitro study. Melanoma Research, v. 29, n. 3, p. 270-280, . (17/02549-0)

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