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Synthesis of Seleno-coumarins to detection and interception of endogenous oxidizing entities

Grant number: 18/10877-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2018
Effective date (End): June 30, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Alcindo Aparecido dos Santos
Grantee:Lucas dos Santos Cunha
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Fluorescent probes capable of detecting entities involved in biological disorders may find important applications in diagnosis and even treatment of certain disorders such as by intercepting a particular entity or blocking some metabolic pathway. An efficient way to identify specific pathologies, especially those associated with oxidative processes is by detection of oxidizing entities,that here, for practical purposes, we will call endogenous oxidants (OxEn).

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