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The influence of the ACTN3 gene polymorphism in the responsiveness to the post-activation potentiation

Grant number: 18/05336-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2018
Effective date (End): November 27, 2019
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Leonardo Coelho Rabello de Lima
Grantee:Guilherme Beneduzzi Mantovani
Host Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil
Associated scholarship(s):19/00511-1 - The effect of different warm-up protocols on post-activation potentiation in high level trained athletes, BE.EP.IC


Polymorphisms in the ACTN3 gene affect the ultrastructural morphology of sarcomeres that can influence fiber type distribution. The predominance of specific fiber types in lower limb muscles might improve performance in endurance or explosive events. Recent data shows that homozygosis for the R577X allele of the ACTN3 gene leads to greater performance in endurance events while R577R homozigotic individuals perform better in explosive events. Concurrently, it is known that responsiveness to postactivation potentiation (PAP) in influenced by fiber type distribution with type IIx fibers responding the most to pre-activation. The aim of this study is to investigate the influence of ACTN3 polymorphisms on responsiveness to PAP. Our hypothesis is that R577RR individuals respond better to PAP due to greater proportions of type IIx fibers. Untrained males will be assigned to two groups based on their ACTN3 polymorphism homozygosis: XX and RR. Their countermovement jump height will be determined in two distinct conditions: control (no pre-activation) and potentiated (four minutes after performing five squats with a 5RM load). Different conditions will be randomly performed in separate days. All participants will undergo as many familiarization sessions as necessary to achieve reproducible countermovement jump height before fata collection. Differences between conditions and groups will be compared by mixed-design factorial ANOVA (groupsvs conditions). Tukey´s post hoc tests will be performed upon identification of a significant interaction effect. Significance level will be set as p < 0.05.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GUILHERME BENEDUZZI MANTOVANI; RENAN VIEIRA BARRETO; VICTOR ALVINO DE SOUZA; CARLOS ROBERTO BUENO JÚNIOR; CLAUDIO DE OLIVEIRA ASSUMPÇÃO; CAMILA COELHO GRECO; BENEDITO SÉRGIO DENADAI; LEONARDO COELHO RABELLO DE LIMA. A influência do polimorfismo R577X do gene ACTN3 na responsividade à melhora de desempenho de salto pós-ativação em indivíduos jovens destreinados. Rev. bras. cineantropom. desempenho hum., v. 23, . (19/00511-1, 18/05336-0)

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