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Systemic treatment with canabidiol in a neuropathic pain model: evaluation of the sensorial-discriminative and emotional-motivacional components pain sensitivity

Grant number: 18/06877-5
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2018
Effective date (End): June 30, 2022
Field of knowledge:Humanities - Psychology - Physiological Psychology
Principal Investigator:Christie Ramos Andrade Leite Panissi
Grantee:Gleice Kelli Ribeiro da Silva Cardoso
Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:14/50891-1 - INCT 2014: Translational Medicine, AP.TEM
Associated scholarship(s):19/12439-3 - Cannabinoids in the amygdala-parabrachial circuit, and the regulation of pain, BE.EP.DR


The conditions of persistent or chronic pain are often accompanied by disordersemotional and cognitive. These dysfunctional or maladaptive changes in aversive/motivational circuits probably contribute to the challenges of treating neuropathic pain. However, experimental and methods used to measure the affective dimension of pain are still scarce in the literature. Considering the neurochemistry involved in nociceptive modulation, the cannabinoid system is an important endogenous system that participates in the circuit of pain sensitivity, functioning in parallel to the system and playing crucial roles in the development and resolution of pain states, as well as in the affective and cognitive aspects of pain. The distribution of the cannabinoid system in the neuraxis is extensive, with endogenous cannabinoids (CB) and their receptors found throughout the central nervous system. Still, recent studies suggest that cannabinoids act not only through action on cannabinoid receptors (CB), but also by modulation of vanilloid receptors (TRPV1). This study will if the systemic treatment with CBD modulates allodynia and hyperalgesia in a neuropathic pain model. In particular, it will be assessed whether CBD administration specifically alters the behavioral response (thermal and mechanical), that is to say, of the discriminating component of pain, and/or of the affective-motivational component. To achieve this, the von Frey Test (allodyniamechanics), hot plate and acetone test (heat and cold sensitivity the test of preference to the conditioned place (will evaluate the emotional affective component of the pain). In asecond stage, the expression of TRPV1 and CB1 receptors, as well as FOS encephalic components involved in the modulation of the affective-motivational component of pain. In particular, the following structures were evaluated: insular cortex, cingulate gyrus cortex, amygdala and hippocampus. Considering these objectives, we intend to understand the mechanisms that would be involved inmodulation of neuropathic pain and related to cannabinoid neurotransmission in brain areas addressed in this study. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LAZARINI-LOPES, WILLIAN; SILVA-CARDOSO, GLEICE KELLI. Neuroplastic alterations in cannabinoid receptors type 1 (CB1) in animal models of epileptic seizures. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 137, p. 17-pg., . (19/05957-8, 18/06877-5, 21/14198-3)
SILVA-CARDOSO, GLEICE K.; LAZARINI-LOPES, WILLIAN; PRIMINI, EDUARDO OCTAVIANO; HALLAK, JAIME E.; CRIPPA, JOSE A.; ZUARDI, ANTONIO W.; GARCIA-CAIRASCO, NORBERTO; LEITE-PANISSI, CHRISTIE R. A.. Cannabidiol modulates chronic neuropathic pain aversion behavior by attenuation of neuroinflammation markers and neuronal activity in the corticolimbic circuit in male Wistar rats. Behavioural Brain Research, v. 452, p. 16-pg., . (21/13622-6, 19/12439-3, 22/05471-0, 18/06877-5, 14/50891-1)
LAZARINI-LOPES, WILLIAN; SILVA-CARDOSO, GLEICE KELLI; CORTES DE OLIVEIRA, JOSE ANTONIO; CORREA PASSOS, LUIZ AUGUSTO; SALGADO, ANDREIA RUIS; RODRIGUES DEMOLIN, DANIELE MASSELLI; ANDRADE LEITE-PANISSI, CHRISTIE RAMOS; GARCIA-CAIRASCO, NORBERTO; COIMBRA, NORBERTO CYSNE. Inherited pain hypersensitivity and increased anxiety-like behaviors are associated with genetic epilepsy in Wistar Audiogenic Rats: Short- and long-term effects of acute and chronic seizures on nociception and anxiety. Epilepsy & Behavior, v. 141, p. 13-pg., . (21/14198-3, 21/13622-6, 20/15050-7, 21/14073-6, 19/05957-8, 18/06877-5)
SILVA-CARDOSO, GLEICE K.; LAZARINI-LOPES, WILLIAN; HALLAK, JAIME E.; CRIPPA, JOSE A.; ZUARDI, ANTONIO W.; GARCIA-CAIRASCO, NORBERTO; LEITE-PANISSI, CHRISTIE R. A.. Cannabidiol effectively reverses mechanical and thermal allodynia, hyperalgesia, and anxious behaviors in a neuropathic pain model: Possible role of CB1 and TRPV1 receptors. Neuropharmacology, v. 197, . (19/05957-8, 18/06877-5, 14/50891-1)
LAZARINI-LOPES, WILLIAN; SILVA-CARDOSO, GLEICE KELLI; ANDRADE LEITE-PANISSI, CHRISTIE RAMOS; GARCIA-CAIRASCO, NORBERTO. Increased TRPV1 Channels and FosB Protein Expression Are Associated with Chronic Epileptic Seizures and Anxiogenic-like Behaviors in a Preclinical Model of Temporal Lobe Epilepsy. BIOMEDICINES, v. 10, n. 2, p. 19-pg., . (18/06877-5, 19/05957-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CARDOSO, Gleice Kelli Ribeiro da Silva. Cannabidiol in a preclinical model of neuropathic pain: an assessment of sensory, emotional and inflammatory aspects related to the modulation of pain sensitivity. 2022. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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