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Assessment of constitutive rheological models for the tissue and of its tickness on the prediction of Brain Aneurysms rupture

Grant number: 17/18514-1
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2018
Effective date (End): June 29, 2022
Field of knowledge:Engineering - Mechanical Engineering - Thermal Engineering
Principal Investigator:José Luiz Gasche
Grantee:Iago Lessa de Oliveira
Host Institution: Faculdade de Engenharia (FEIS). Universidade Estadual Paulista (UNESP). Campus de Ilha Solteira. Ilha Solteira , SP, Brazil
Associated scholarship(s):19/19098-7 - Implementing solid models for fluid-solid interaction solution of flow in intracranial aneurysms in solids4foam, BE.EP.DR


Aneurysms are abnormalities formed in some regions of the human vascular systemand are characterized by dilated and thin regions of the arterial wall. One of the mostcommon types occurs inside the brain arteries in the Circle of Willis. These Intracranial Aneurysms are extremely dangerous, because in case of rupture they can cause sub-arachnoid hemorrhage, with consequent death or presence of permanent damage to the patient. Causes of Aneurysms have been investigated for a long time, and researchers agree that hemodynamic effects play a key role in the formation, growth, and rupture of Brain Aneurysms. With the development of scanning techniques of the cerebral vascular system, it has been possible to obtain the geometry of Aneurysms and numerical methods for the solution of blood flow have begun to be used. Since then, several researchers have been investigating the influence of biological and hemodynamic variables on Aneurysms rupture. However, only recently the fluid-structure interaction problem has been studied for the Aneurysm rupture problem, in which the variables of the Aneurysm wall - such as tensions and deformations - are essential to study the rupture event. The present work consists of a numerical investigation of the best constitutive model for the tissue of the Aneurysm wall in order to predict its rupture. Moreover, the model must account for the varying thickness of the Aneurysm and arteries walls. We will use the open-source software foam-extend which has a library for solving fluid-structure interaction problems. Geometric models of real Aneurysms will be used for the simulations. After the simulations, the fields of velocity, pressure, wall shear stress and wall tension will be analyzed in order to identify the possibility of rupture of the Aneurysm. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA, I. L.; SANTOS, G. B.; MILITZER, J.; BACCIN, C. E.; TATIT, R. T.; GASCHE, J. L.. A longitudinal study of a lateral intracranial aneurysm: identifying the hemodynamic parameters behind its inception and growth using computational fluid dynamics. Journal of the Brazilian Society of Mechanical Sciences and Engineering, v. 43, n. 3, . (17/18514-1)
OLIVEIRA, IAGO L.; SANTOS, GABRIEL B.; GASCHE, JOSE L.; MILITZER, JULIO; BACCIN, CARLOS E.. Non-Newtonian Blood Modeling in Intracranial Aneurysm Hemodynamics: Impact on the Wall Shear Stress and Oscillatory Shear Index Metrics for Ruptured and Unruptured Cases. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, v. 143, n. 7, . (17/18514-1)
OLIVEIRA, I. L.; CARDIFF, P.; BACCIN, C. E.; GASCHE, J. L.. A numerical investigation of the mechanics of intracranial aneurysms walls: Assessing the influence of tissue hyperelastic laws and heterogeneous properties on the stress and stretch fields. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 136, p. 16-pg., . (17/18514-1, 19/19098-7)
OLIVEIRA, I. L.; CARDIFF, P.; BACCIN, C. E.; TATIT, R. T.; GASCHE, J. L.. On the major role played by the lumen curvature of intracranial aneurysms walls in determining their mechanical response, local hemodynamics, and rupture likelihood. COMPUTERS IN BIOLOGY AND MEDICINE, v. 163, p. 14-pg., . (19/19098-7, 17/18514-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
OLIVEIRA, Iago Lessa de. On the mechanics of intracranial aneurysms walls: numerical assessment of the influence of tissue hyperelastic laws and heterogeneity and the major role played by curvature on pathways to rupture. 2022. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Engenharia. Ilha Solteira Ilha Solteira.

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