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Di-isononyl phthalate an emerging contaminant in freshwater: what are the risks for apoptotic and autophagyc processes in zebrafish gonads

Grant number: 18/10495-0
Support Opportunities:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): September 01, 2018
Effective date (End): February 28, 2019
Field of knowledge:Biological Sciences - Physiology - Compared Physiology
Principal Investigator:Renata Guimarães Moreira Whitton
Grantee:Filipe Guilherme Andrade de Godoi
Supervisor: Oliana Carnevali
Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: Università Politecnica delle Marche (UNIVPM), Italy  
Associated to the scholarship:17/07139-5 - Adjustments on males reproductive physiology of Astyanax altiparanae (Teleostei:Characidae) exposed to emerging compounds, BP.MS


The presence of several substances on plastic formulations has been hazardous due to the potential of endocrine disruptor activity of these compounds and possible harmful effects to humans. Endocrine Disruptors Chemicals (EDCs) are harmful to the reproductive physiology of animals, specially in critical periods of life like juveniles, puberty, intrauterine life, etc. These compounds have also been present in aquatic environments and classified as emerging compounds due to the possible effects in the aquatic biota. In this sense, the physiological process involving the reproduction pathways, as gametogenesis and atresia, are relevant for the maintenance of reproductive tissue homeostasis in the animals. The reproductive pathways include some main processes called autophagy and atresia, they are essential to regulate germinative cells growth and degeneration, the enzymatic cascade and different genes expression involved are necessary to the evaluation of toxicological effects of these emerging compounds, as the fthalates. Considering the importance of reproductive physiology on the ecotoxicological studies and the impact of these substances in aquatic life, the present study aims to evaluate the effects of di-isononyl phthalate (DiNP) in the autophagy and apoptosis of Danio rerio gonads, commonly known as zebrafish. The study will be carried out in bioassays using a multidisciplinary approach using transcriptome, proteomic and a comparative anatomic study. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GODOI, FILIPE G. ANDRADE; FORNER-PIQUER, ISABEL; RANDAZZO, BASILIO; HABIBI, HAMID R.; LO NOSTRO, FABIANA L.; MOREIRA, RENATA GUIMARAES; CARNEVALI, OLIANA. Effects of Di-Isononyl Phthalate (DiNP) on Follicular Atresia in Zebrafish Ovary. FRONTIERS IN ENDOCRINOLOGY, v. 12, . (17/07139-5, 14/16320-7, 18/10495-0, 17/11530-1)

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