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Encapsulation of curcumin in BioMOF-100 functionalized with folate: development and evaluation of potential in the treatment of Breast Cancer

Grant number: 17/26065-2
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2018
Effective date (End): September 30, 2021
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Marlus Chorilli
Grantee:Renata Carolina Alves
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated scholarship(s):18/26405-0 - Surface modification with folic acid in a curcumin- loaded mesoporous metal-organic framework by "click" reactions, BE.EP.DR

Abstract

Breast Cancer is the most frequent and the most frequent cause of Cancer death in women, representing the fifth leading cause of Cancer death in general. Particular interest are unfavorable triple negative breast tumors which may express folate receptors, which may be useful for designing strategies for targeting the tumor therapy. Curcumin (CCM), extracted from the curcuma longa plant, has chemopreventive and antitumor activities against some aggressive and recurrent Cancer s, such as breast Cancer. Despite its great potential in antitumor therapy, CCM has limitations, which include low solubility in water at physiological pH and acid conditions, rapid hydrolysis at alkaline pH and instability in the presence of light. In this way, a release system that allows efficient administration of CCM is of paramount importance. In this sense, Biocompatible Metal Organic Frameworks (BioMOFs), polymers of coordination, can be promising and attractive for incorporation and modified release of this drug. Thus, this project aims to encapsulate CCM in folate-functionalized BioMOF-100 and to evaluate the potential of this carrier in the treatment of Breast Cancer in vitro and in vivo models. The physicochemical characterization of the system will involve evaluations of crystallinity, morphology, thermal stability, drug encapsulation efficiency and quantification of folate present in the carrier after functionalization. Finally, the system will be evaluated in vitro by cytotoxicity assay in cell lines that express or not the folate receptor and in vivo, in an acute toxicity model and triple negative breast Cancer. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVES, RENATA CAROLINA; QUIJIA, CHRISTIAN RAFAEL; DA SILVA, PATRICIA BENTO; FARIA, RAQUEL SANTOS; CABRAL MORAIS, AMANDA ALENCAR; LOPES DE ARAUJO, HENRIQUE LOBACK; DE AZEVEDO, RICARDO BENTES; CHORILLI, MARLUS. Folic acid-conjugated curcumin-loaded bioMOF-101 for breast cancer therapy. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 86, p. 11-pg., . (17/26065-2)
ALVES, RENATA CAROLINA; PEROSA FERNANDES, RICHARD; DE FARIAS, RENAN LIRA; DA SILVA, PATRICIA BENTO; FARIA, RAQUEL SANTOS; QUIJIA, CHRISTIAN RAFAEL; FREM, REGINA CELIA GALVAO; AZEVEDO, RICARDO BENTES; CHORILLI, MARLUS. Fabrication of Functional bioMOF-100 Prototype as Drug Delivery System for Breast Cancer Therapy. PHARMACEUTICS, v. 14, n. 11, p. 19-pg., . (17/26065-2)
ALVES, RENATA C.; SCHULTE, ZACHARY M.; LUIZ, MARCELA T.; DA SILVA, PATRICIA BENTO; FREM, REGINA C. G.; ROSI, NATHANIEL L.; CHORILLI, MARLUS. Breast Cancer Targeting of a Drug Delivery System through Postsynthetic Modification of Curcumin@N-3-bio-MOF-100 via Click Chemistry. Inorganic Chemistry, v. 60, n. 16, p. 11739-11744, . (17/26065-2, 18/26405-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ALVES, Renata Carolina. Curcumin encapsulation in folate-functionalized bioMOF-100: development and evaluation of its potential in the treatment of breast cancer. 2021. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Farmacêuticas. Araraquara Araraquara.

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