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Citrus Flavanones- mechanisms of protection of pancreatic-beta cells under oxidative stress

Grant number: 18/03965-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2018
Effective date (End): September 30, 2019
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Science
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Neuza Mariko Aymoto Hassimotto
Grantee:Sara Lima Anacleto
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/07914-8 - FoRC - Food Research Center, AP.CEPID
Associated scholarship(s):18/26584-2 - Effect of citrus flavanones in Min6 cells under oxidative stress: Proteomic approach, BE.EP.MS


Insulin resistance is characterized by low insulin response in peripheral tissues, oxidative stress and the inflammatory state in several tissues, including pancreatic tissue, which leads to impairment of function, such as insulin synthesis and secretion. Cholesterol is one of the trigger of the oxidative stress in the pancreatic-beta cell, generating high level of reactive oxygen species, such as the superoxide anion. Currently, the intake of bioactive compounds from fruits and vegetables is one of the alternative procedures for mitigate metabolic disorders, preventing the evolution of insulin resistance. Bioactive compounds, such as flavanones, a subclass of flavonoids, present anti-inflammatory and antioxidant activities, which could reduce oxidative stress in beta cells, improving its function. Orange is the most consumed fruit by the Brazilian population, being the main source of flavanones that could affect positively on health. Thus, the purpose of this project is evaluate the protection effect of flavanones on pancreatic-beta cells under oxidative stress. For this, pancreatic-beta cells (Min6 line) will be treat with phase II metabolites of flavanones, and catabolites produced from intestinal microbiota, since they are the main circulating compounds in the blood. Furthermore, in order to identify possible molecular targets of the action of flavanones on pancreatic dysfunction, a proteomic approach is proposed. This study, together with biochemical and physiological parameters, will allow information on how flavanones can exert a protective effect on pancreatic-beta cells preventing the development of chronic diseases, such as insulin resistance and Diabetes. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANACLETO, SARA L.; MILENKOVIC, DRAGAN; KROON, PAUL A.; NEEDS, PAUL W.; LAJOLO, FRANCO MARIA; HASSIMOTTO, NEUZA M. A.. Citrus flavanone metabolites protect pancreatic-beta cells under oxidative stress induced by cholesterol. FOOD & FUNCTION, v. 11, n. 10, p. 8612-8624, . (13/07914-8, 18/03965-0)
FRAGA, LAYANNE NASCIMENTO; ANACLETO, SARA LIMA; MILENKOVIC, DRAGAN; LAJOLO, FRANCO MARIA; AYMOTO HASSIMOTTO, NEUZA MARIKO. Citrus flavanone metabolites protect pancreatic beta-cells against cholesterol stress through a multi-proteomic mechanism. FOOD & FUNCTION, v. 13, n. 24, p. 19-pg., . (18/26584-2, 18/03965-0, 13/07914-8)
FRAGA, LAYANNE NASCIMENTO; MILENKOVIC, DRAGAN; ANACLETO, SARA LIMA; SALEMI, MICHELLE; LAJOLO, FRANCO MARIA; HASSIMOTTO, NEUZA MARIKO AYMOTO. Citrus flavanone metabolites significantly modulate global proteomic profile in pancreatic beta-cells under high-glucose-induced metabolic stress. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1871, n. 3, p. 21-pg., . (13/07914-8, 18/26584-2, 18/03965-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ANACLETO, Sara Lima. Citrus Flavanones - mechanisms of protection of pancreatic-βcells under oxidative stress. 2020. Master's Dissertation - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.

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