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Cardiac remodeling in spontaneously hypertensive rats: role of exercise training associated or not with perindopril

Grant number: 18/02021-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2018
Effective date (End): December 31, 2018
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Sandra Lia do Amaral Cardoso
Grantee:Melissa Ganeko Ligeiro
Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil


Among all consequences of hypertension, cardiovascular diseases are the major contributing to mortality. Factor such cardiac hypertrophy, fibrosis and myocardium capillary density loss are involved. Spontaneously hypertensive rats (SHR) have cardiac remodeling due to hypertension and because of that, several pharmacological and non-pharmacological treatments are used. Among inhibitors of angiotensin converting enzyme (ACEi) drugs, perindopril has been shown to be efficient to improve hypertension and cardiac remodeling. Aerobic exercise training (T), on the other hand, has been used as non-pharmacological treatment of hypertension and it is also efficient to ameliorate cardiac remodeling and hypertension, however, almost nothing is known about the association of these two treatments. The objective of this present study is to analyze the effects of exercise training, associates or not with pharmacological treatment with perindopril on myocardium remodeling in SHR rats. SHR rats will be divided in 5 groups: sedentary control (SC, n=10), sedentary + perindopril (SP, n=10), trained control (TC, n=10) e trained + perindopril (TP, n=10) and also Wistar rats as normotensive controls. Aerobic training will be performed on treadmill, 1h/day, 5days/week, during 8 weeks at 60% of maximal physical capacity. SP and TP groups will be daily treated with perindopril (3 mg / kg body weight, gavage) during all experimental protocol. SC and TC groups will receive saline. At the end of training period, pulse wave velocity and blood pressure will be measured. Myocardium will be removed for histological measurements. ANOVA one way analysis with Tukey post-hoc will be used (p<0.05).

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