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Effect of omega-3 polyunsaturated fatty acids plus low-dose aspirin daily supplementation on inflammatory parameters of patients with generalized aggressive periodontitis: pilot study

Grant number: 18/02161-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2018
Effective date (End): December 31, 2018
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Mauro Pedrine Santamaria
Grantee:Tayná Lopes da Silva
Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil


Periodontitis is an inflammation that leads to destruction of gingival and periodontal tissues. Among the forms of periodontal disease, aggressive periodontitis (AgP) has the fastest rate of progression and affects young and systemically healthy individuals. Although studies show that the association of an antimicrobial with mechanical therapy promotes better results, the large-scale use of antibiotic agents may generate resistance in the periodontal microbiota. Therefore, other forms of therapy need to be developed. In patients with AgP, the interindividual variation in response to therapy tends to be generalized. Thus, research involving modulation of host inflammatory responses may be of great value to these patients. Recently, the daily supplementation of omega-3 polyunsaturated fatty acids and aspirin was proposed as adjunctive therapy for the treatment of chronic periodontitis, demonstrating good clinical results. Aspirin showed great results by inducing the production of lipoxins triggered by aspirin, which are more bioactive than common lipoxins and have better inflammatory resolution properties. Studies have shown that omega-3 polyunsaturated fatty acids serve as substrate for the enzymatic conversion of lipidic mediators called resolvins and protectins, which present great potential for protective and pro-resolutive actions in inflammatory diseases, such as periodontitis. Thus, the aim of this pilot study will be to evaluate the effect of 3 g of omega-3 polyunsaturated fatty acids and 100 mg of aspirin daily supplementation over a period of 90 days on inflammatory parameters of patients with generalized aggressive periodontitis. Twenty patients will be selected. Probing depth, gingival index, and PISA will be evaluated at baseline and 3 months post-operatively. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ARAUJO, CASSIA F.; ANDERE, NAIRA M. R. B.; CASTRO DOS SANTOS, NIDIA C.; MATHIAS-SANTAMARIA, INGRID F.; REIS, AURELIO A.; DE OLIVEIRA, LUCIANE D.; JARDINI, MARIA A. N.; CASARIN, RENATO C. V.; SANTAMARIA, MAURO P.. Two different antibiotic protocols as adjuncts to one-stage full-mouth ultrasonic debridement to treat generalized aggressive periodontitis: A pilot randomized controlled clinical trial. Journal of Periodontology, v. 90, n. 12, p. 10-pg., . (18/02161-5, 14/22078-4)

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