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Determination of the antiproliferative activity of active compounds obtained from different structures of the seeds and seedlings of Glycine max

Grant number: 18/05717-4
Support type:Scholarships abroad - Research Internship - Scientific Initiation
Effective date (Start): May 21, 2018
Effective date (End): August 20, 2018
Field of knowledge:Agronomical Sciences - Agricultural Engineering - Process Engineering of Agricultural Products
Principal researcher:Regildo Márcio Gonçalves da Silva
Grantee:Bianca de Arruda Leite
Supervisor abroad: Stefan Wolfl
Home Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil
Research place: Heidelberg University, Germany  
Associated to the scholarship:17/13316-7 - Development of a culture method of g. max cells (soybean) in suspension for the production of active compounds with antioxidant, antiglandal and antitumor potential, BP.IC


The present scholarship aims to evaluate the biological activity through in vitro tests, using cancer cell lines, active compounds present in different structures of the seed (cotyledon, embryo and integument) and seedling (radicle and caulci) of Glycine max (soybean). To do so, we will perform the following lines of study: Cell proliferation assay, Apoptosis induction, Intracellular ROS formation and Cell death detection with Annexin V/propidium iodide together with the research group of the University of Heidelberg. This internship abroad is justified because there is the perspective of the development of a culture method of G. max cells (soybean) in suspension to produce active compounds with anticancer potential that is already in execution, with the possible mechanism of action involving the antioxidant and antiglycerin activity, and the new biological assays that will be developed abroad may corroborate with the results of the research project in the country. The internship project could also result in a scientific partnership between UNESP and the University of Heidelberg, both with the personal and professional gains of the undergraduate student who will experience the research experience at one of the most renowned molecular biotechnology research centers. (AU)

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