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Effects of photobiomodulation therapy on inflammatory mediators in patients with chronic non-specific low back pain: a randomized placebo-controlled trial

Grant number: 17/18863-6
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): June 13, 2018
Effective date (End): June 12, 2019
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Leonardo Oliveira Pena Costa
Grantee:Shaiane da Silva Tomazoni
Supervisor: Jan Magnus Bjordal
Host Institution: Pró-Reitoria de Pós-Graduação, Pesquisa e Extensão. Universidade Cidade de São Paulo (UNICID). São Paulo , SP, Brazil
Research place: University of Bergen, Norway  
Associated to the scholarship:16/10265-0 - Effects of photobiomodulation therapy on chronic non-specific low back pain: placebo-controlled randomized clinical trial, BP.PD

Abstract

Background: Low back pain (LBP) is ranked as one of the most prevalent health conditions. It is likely that some inflammatory mediators could be associated with pain and disability in these patients. Photobiomodulation therapy (PBMT) is a non-pharmacological therapy often used in patients with LBP that decrease release of inflammatory mediators and accelerate muscle repair in different muscle skeletal conditions, as mechanisms of action. However, to date there are no studies that evaluated the effects of PBMT on the levels of inflammatory markers in patients with LBP. Objectives: This project aims to investigate if there is presence of local inflammatory markers, in the longissimus dorsi muscle, in patients with chronic non-specific LBP. We also aim to evaluate the acute effects of PBMT on the local or systemic inflammatory markers and intensity of pain in these patients. Methods and analysis: We will be conduct two separate studies: a cross sectional pilot study (to determine the presence of local inflammatory markers) and a randomized placebo-controlled trial with blinded patients, assessors and treatment providers (to evaluate the acute effects of PBMT on inflammatory markers). For this, 18 patients with chronic non-specific LBP will be recruited and one single session of treatment will be provided with patients receiving either placebo or active PBMT The primary outcome of the cross sectional study will be the levels of inflammatory markers in patients with chronic non-specific LBP compared to healthy individuals. The outcomes of second study will be the levels of inflammatory markers and pain intensity. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TOMAZONI, SHAIANE S.; COSTA, LEONARDO O. P.; JOENSEN, JON; STAUSHOLM, MARTIN B.; NATERSTAD, INGVILL F.; ERNBERG, MALIN; LEAL-JUNIOR, ERNESTO CESAR P.; BJORDAL, JAN M.. Photobiomodulation Therapy is Able to Modulate PGE(2) Levels in Patients With Chronic Non-Specific Low Back Pain: A Randomized Placebo-Controlled Trial. Lasers in Surgery and Medicine, v. 53, n. 2, . (17/18863-6)
TOMAZONI, SHAIANE SILVA; PENA COSTA, LEONARDO OLIVEIRA; JOENSEN, JON; STAUSHOLM, MARTIN BJORN; NATERSTAD, INGVILL FJELL; PINTO LEAL-JUNIOR, ERNESTO CESAR; BJORDAL, JAN MAGNUS. Effects of photobiomodulation therapy on inflammatory mediators in patients with chronic non-specific low back pain Protocol for a randomized placebo-controlled trial. MEDICINE, v. 98, n. 15, . (17/18863-6)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.